Karteikarten
HSV1
Karten in diesem Stapel (28)
- 1Virus TypeEnveloped, with glycoprotein spikes
- 2Virus ShapeIcosahedral
- 3Primary Infection (Children/Young Adults)Mild to extensive lesions on the mouth and lips
- 4Secondary Infection/RecurrenceRepeated cold sores in the same place
- 5GenomeDs, with both strands coding
- 6Genes20% unique to HSV1, and created by differential splicing
- 7Gene Control/Life CycleHave latent & lytic cycles depending on the nuclear environment
- 8Location of ReplicationNucleus
- 9Productive/Lytic Cycle- LocationInfects host skin cells
- 10Lytic Genome CycleAlpha-T/F activates early genes in a specific sequence using host polymerase
- 11Lytic Cycle- Gene Expression Wave 1Alpha, in the 'Early Intermediate' Stage (these genes continue production throughout later stages)
- 12Lytic Cycle- Gene Expression Wave 2Beta, in the 'Early' Stage (these genes continue production throughout later stages)
- 13Lytic Cycle- Gene Expression Wave 3Gamma, in the 'Late' Stage
- 14Latent Cycle LocationNeurones near initial infection site
- 15Latent Cycle GenomeGenome is packaged rapidly in host cell chromatin and silenced
- 16No of Origins of ReplicationThree (of lytic replication) but only uses one
- 17Replication of HSV1- Bases in OriginRich in A-T to make replication easier
- 18Replication of HSV1- Ori ProteinOri Binding Protein binds to specific elements for unwinding
- 19Replication of HSV1- Helicase PrimaseStarts replication before DNA polymerase takes over
- 20Replication In CellsIn cells that aren't replicating
- 21Replication of HSV1- DNA LengthDNA several genomes long is made, then cut into individual genomes for virions
- 22Replication of HSV1- DNA ShapeInitially linear, then becomes circular
- 23AssemblySelf folding proteins form capsule, which are then cleaved so DNA can enter
- 24AntiviralsAcyclovar
- 25Acyclovar ActivationWorks by P drug inside viral enzymes, which traps it in cells so cell can add two more P
- 26Acyclovar RoleBlocks DNA synthesis, inhibits viral DNA polymerase
- 27A1C316Inhibit Helicase/Primase Inhibitor that prevents the production of short primers for replication
- 28Bicyclic Nucleotide AnaloguesInhibits polymerase in VZV (Chicken pox)
Informationen
- Beschreibung
- Virology (HSV) Karteikarten am HSV1 , erstellt von gina_evans0312 am 14/04/2014.
- Erstellt von
- gina_evans0312
- Aufrufe
- 325
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