inflammation

inflammation

1. what?

   • Immune response
     • Innate immunity
     • inflammation
     • adaptive immunity

2. characterized by?

   • Redness
   • pain
   • heat
   • swelling
   • loss of function
   • -due to dilation of arterioles, capillaries & venules
     • Diapedesis: WBC adhering to inner wall of site

3. why?

   • Infection
   • nutrient deprivation
   • temperature extremes

4. Goal?

   • Prevent and limit infection and further damage

5. steps

   • 1-Mast cell stimulation
     • Degranulation
       • Histamine: causes temporary rapid constriction of large vessel walls
         • H1 receptor (proinflammatory)
         • H2 receptor (anti-inflammatory)
       • Neutrophil chemotactic factor
       • Eosinophil chemotactic factor of anaphylaxis
     • synthesis of lipid-derived chemical mediators
       • Leukotrienes
       • Prostaglandins
         • vasodialator
         • pain
         • fever
       • Platelet-activating factor
   • 2-Protein systems
     • Complement system
     • Coagulation system
     • Kinin system
   • 3-Phagocytosis
     • Neutrophils
     • Monocytes and macrophages