Antibiotics/Antifungals/Antivirals/Antimycobacterials/Anticancer

Question

Which of the following is a correct description of Ludwig's Angina?

Answer 1

Caused by anaerobe infection

Answer 2

It occurs in children with concomitant dental infections

Answer 3

It is not life-threatneing

Answer 4

Caused by infection from bacteroids, staphylococci, and streptococci

Answer 5

Inhibition of cell wall synthesis

Answer 6

Selective Inhibition

Answer 7

Suppression of DNA synthesis

Answer 8

Common targets

Answer 9

Unique drug targets

Answer 10

Alteration of cell membrane permeability

Answer 11

Natural or synthetic substances used to suppress growth or kill bacteria/ single cell organisms

Answer 12

Substances that act against or destroy infections (Fungal/Viral/Bacteria)

Answer 13

Substances that destroy or supress the growth or multiplcation of bacteria

Answer 14

Substances produced by bacteria that can destroy or suppress the growth or multiplication of bacteria or prevent the action of bacteria

Answer 15

Penicillin V

Answer 16

Ampicillin

Answer 17

Penicillin G

Answer 18

Binds to ribosome 30s to prohibit protein synthesis

Answer 19

Disrupts the integrity of the baceterial cell wall by displacing calcium and magnesium

Answer 20

Inhibits the cross-linkages between the peptidoglycan polymer strands

Answer 21

Disrupts the integrity of the cell membrane by displacing calcium and magnesium

Answer 22

Transpeptidase

Answer 23

Peptidyl transferase

Answer 24

Beta lactamase

Answer 25

Transcriptase

Answer 26

They block conversion of PABA into dihydrofolic acid

Answer 27

They inhibit DNA gyrase and Topoismerase enzymes, preventing supercoiling

Answer 28

They inhibit peptidyl transferase, inhibiting binding of tRNA to mRNA

Answer 29

They bind to the dihydroflate reductase (DHFR) enzyme, thus preventing production of folic acid

Answer 30

Cephalosporins

Answer 31

Macrolides

Answer 32

Metronidazole

Answer 33

Tetracyclines

Answer 34

Bacteriophages

Answer 35

Transposons

Answer 36

Enzymatic inactvation

Answer 37

Antibiotic antagonism or interactions

Answer 38

Insensitivity to apoptosis

Answer 39

Overproduction of target sites

Answer 40

Pancreatic

Answer 41

More likely to occur with narrow spectrum antibiotics

Answer 42

Occurs with transfer of plasmids and transposons

Answer 43

They are easy to treat

Answer 44

May be opportunistic infections with viruses such as Candidda albicans and Histoplasmosis

Answer 45

Used after surgery to prevent wound infections

Answer 46

Used after a potential expsoure

Answer 47

To prevent an oral infection after having a dental procedure

Answer 48

In immunocompromised patients to prevent reactivation of latent reactions

Answer 49

Macrolides

Answer 50

Metronidazole

Answer 51

Tetracycline

Answer 52

Cefadroxil

Answer 53

Cephalexin

Answer 54

Aminoglycosides

Answer 55

Ciprofloxacin

Answer 56

Clindamycin

Answer 57

Limited vascularity or blood flow to tissue

Answer 58

Blood concentration too low

Answer 59

Impaired host to immune system

Answer 60

Failure to activate the antibiotics

Answer 61

Fluroquinolones

Answer 62

Sulfonamides

Answer 63

Penicillins

Answer 64

Cephalsporins

Answer 65

Fluroquinolones

Answer 66

Macrolides

Answer 67

Penicillins

Answer 68

Stevens Johnsons

Answer 69

Superinfection

Answer 70

Teratology

Answer 71

Increased effects of oral contraceptives

Answer 72

One of these two can be used for treatment of Ludwig's Angina

Answer 73

Used for mixed aerobic-anerobic infections

Answer 74

Used for head, neck, and dental infections

Answer 75

These are all correct

Answer 76

Skin and soft tissue infections

Answer 77

Broad spectrum Enterobacter

Answer 78

Klebsiella and enterocci

Answer 79

Ear, nose and throat, H. pylori

Answer 80

Amoxicillin

Answer 81

Methicillin

Answer 82

These are all antistaphylococcal penicilllins

Answer 83

Peptidyl transferase

Answer 84

Transpeptidase

Answer 85

Transcriptase

Answer 86

Fungal overgrowth

Answer 87

Pseudomembraneous colitis

Answer 88

Oral lesions

Answer 89

Increase renal tubular secretion with use of probenecid

Answer 90

Inactivation with use of aminoglycosides

Answer 91

Disulfram-like reaction

Answer 92

Inhibits metabolism of anticoagulants, increasing risk of bleeding

Answer 93

Resistant to beta lactamases

Answer 94

Narrow spectrum

Answer 95

Ampicillin has less side effects than amoxicillin

Answer 96

Effective against Neissseria gonorrhea and meningitidis

Answer 97

Penicillin V

Answer 98

Penicillin G

Answer 99

Cloxacillin

Answer 100

Amoxicillin

Answer 101

Cloxacillin

Answer 102

Amoxacillin

Answer 103

Clavulanic acid

Answer 104

Ampicillin

Answer 105

Amoxicillin has a molecular structure similar to beta lactam, thus prevents inactivation by beta lactamase

Answer 106

They are ineffective against Salmonella related infections

Answer 107

They are used in immunocompromised patients with mixed infections

Answer 108

They are effective against Klebsiella bacteria

Answer 109

Includes Cefotaxime and Ceftriaxone

Answer 110

Used for UTI and soft tissue abscesses

Answer 111

Effective against Klebsiella and H influenza

Answer 112

Used for treatment of community-acquired pneumonia

Answer 113

Drug of choice for surgical prophylaxis

Answer 114

Used to treat Meningitis

Answer 115

Includes the drug Cefuroxime

Answer 116

Includes the drug Cefepime

Answer 117

They have resistance to beta lacmases

Answer 118

Hightly active against P aeruginosa

Answer 119

Not approved for treatment of meningitis

Answer 120

Best for any H influenza infection

Answer 121

It is used for meningitis

Answer 122

It includes the drug ceftaroline

Answer 123

It is active against Neisseria

Answer 124

Can be used for MRSA

Answer 125

Inhibition of beta 1-3 glycan of bacterial cell wall, preventing cross-linkages

Answer 126

Becomes mechanically reduced to a toxic metabolite, interacting with DNA

Answer 127

Binds to 50s subunit, preventing binding of tRNA to mRNA

Answer 128

Binds to 30s subunit, preventing binding of tRNA to mRNA

Answer 129

Rickettsia

Answer 130

Gram positive bacteria

Answer 131

All are targeted by tetracyclines

Answer 132

Kills flora

Answer 133

Neutropenia

Answer 134

Impairs absorption of antacids

Answer 135

Damages development of bones and teeth

Answer 136

Broad spectrum

Answer 137

Kills Treponema pallidum

Answer 138

Used as an alternative for patients allergic penicillins

Answer 139

Can be bacteriostatic or bacteriocidal, depending on dose

Answer 140

It can be used for MRSA

Answer 141

It can cause Fanconi's syndrome if taken when it is expired

Answer 142

It can bind to ribosome 23s, which makes it unique

Answer 143

Can be used in cases when other macrolides cause fulminant hepatic necrosis

Answer 144

It is bacteriostatic

Answer 145

Binds to 23s ribosome

Answer 146

Can be toxic due to inhibiting mitochondrial protein synthesis

Answer 147

Can be used for Neisseria gonorrhea

Answer 148

Pseudomembranous colitis

Answer 149

Skina nd soft tissue infections

Answer 150

Septic abrotion

Answer 151

Prophylaxis of infective endocarditis

Answer 152

Fungal overgrowth

Answer 153

Thrombocytopenia

Answer 154

Pseudomembranous colitis

Answer 155

Fulminant hepatic necrosis

Answer 156

Sulfonamides

Answer 157

Ampicillin

Answer 158

Erhythromycin

Answer 159

Start on Vancomycin IV

Answer 160

Start on clotrimazole

Answer 161

Start of Metronidazole

Answer 162

Stop all antibiotics

Answer 163

Start on Vancomycin oral

Answer 164

Skin infections

Answer 165

Alternative for patients allergic to Penicillins

Answer 166

Pseudomembranous colitis

Answer 167

Sulfonamides

Answer 168

Penicillins

Answer 169

Macrolides

Answer 170

Tetracyclines

Answer 171

Renal damage from crystalluria

Answer 172

Prolonged QT syndrome

Answer 173

Pseudomembranous Colitis

Answer 174

Neutropenia

Answer 175

Co-trimoxazole

Answer 176

Clotrimazole

Answer 177

Structural analog of PABA

Answer 178

Binds to mammalian DHFR

Answer 179

Structural analog of bacterial DHFR

Answer 180

Binds to bacterial DHFR

Answer 181

Tetracyclines

Answer 182

Sulfonamides

Answer 183

Macrolides

Answer 184

Penicillins

Answer 185

They are chemically reduced to a toxic metabolite which interacts with DNA, resulting in loss of helical structure and essentially cell death

Answer 186

They bind to bacterial ribosomes 30s

Answer 187

They inhibit transpeptidases

Answer 188

They compromise the integrity of the bacterial cell membrane

Answer 189

Gram positive

Answer 190

Gram negative

Answer 191

Phenytoin toxicity

Answer 192

Disulfram reactions

Answer 193

Failure of oral contraceptives

Answer 194

Inhibition of anticoagulant metabolism

Answer 195

Binding to bacterial ribosome 50s

Answer 196

Inhibits DNA gyrase, preventing supercoiling and stopping DNA replication

Answer 197

Inhibits transcriptase, preventing supercoiling and stopping DNA replication

Answer 198

Chemically reduced to a toxic metabolite, interacting with DNA and essentially causing cell death

Answer 199

Ciprofloxacin

Answer 200

Clindamycin

Answer 201

Aminoglycosides

Answer 202

Given by quick infusion for serious systemic infections

Answer 203

May be used where resistance to macrolides has developed in bacterial strains

Answer 204

Inhibits transpeptidase

Answer 205

It is not absorbed by the GI

Answer 206

Penicillin

Answer 207

Erythromycin

Answer 208

Vancomycin

Answer 209

Sulfamethoxazole

Answer 210

Can be used for the treatment of sepsis

Answer 211

Same spectrum as fluroquinolones

Answer 212

Given only PO

Answer 213

Drug monitoring is required

Answer 214

Reversible renal toxicity

Answer 215

Irreversible vestibular toxicity

Answer 216

Neuromuscular blockade

Answer 217

Adding furoseminde can decrease risk of renal damage

Answer 218

Cephalexin

Answer 219

Clindamycin

Answer 220

Tobramycin

Answer 221

Ceftaroline

Answer 222

Streptogramins

Answer 223

Vancomycin

Answer 224

Bacteriophages

Answer 225

Transposon

Answer 226

Used only as topical therapy

Answer 227

Dose adjustment required and dose limited to 6 months

Answer 228

A polyene antifungal that binds to ergosterol in fungal cell membranes

Answer 229

Binds to bacterial RNA polymerase enzyme and inhibits RNA synthesis

Answer 230

Infusion-related reactions

Answer 231

Mild elevation in liver enzymes

Answer 232

Nephrotoxicity

Answer 233

Aminoglycosides

Answer 234

Amphoterecin B

Answer 235

Macrolides

Answer 236

Cryptococcal meningitis

Answer 237

Candida infections

Answer 238

Histoplasmosis

Answer 239

Asperillosis

Answer 240

Echinocandins

Answer 241

Ketoconazole

Answer 242

Itraconazole

Answer 243

Fluconazole

Answer 244

Voriconazole

Answer 245

Miconazole

Answer 246

Clotrimazole

Answer 247

Disrupts microtubule function and inhibits dermatophyte growth

Answer 248

Binds to membrane Ergosterol

Answer 249

Inhibits viral DNA polymerase

Answer 250

Inhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane

Answer 251

Steven Johnson

Answer 252

Increased levels of warfarin

Answer 253

Decreased fluconazole levels wiht isoniazid

Answer 254

Nephrotoxicity

Answer 255

Fluconazole

Answer 256

Itraconazole

Answer 257

Echinocandins

Answer 258

Terbinafine

Answer 259

Griseofulvin

Answer 260

Echinocandins

Answer 261

Ketoconazole

Answer 262

Griseofulvin

Answer 263

Terbinafine

Answer 264

Echinocandins

Answer 265

Ketoconazole

Answer 266

NRTIs inhibit viral DNA relication by binding to reverse transcriptase and inhibit DNA polymerase and NNRTIs act as chain terminators and imtate nucleotides

Answer 267

NNRTIs inhibit viral DNA relication by binding to reverse transcriptase and inhibit DNA polymerase and NRTIs act as chain terminators and imtate nucleotides

Answer 268

NRTIs interact with ohter drugs metabolized by CYP450 enzyme

Answer 269

NRTIs cause Stevens Johnson syndrome

Answer 270

Steven Johnson Syndrome

Answer 271

Cushing-like syndrome

Answer 272

Local injection site reactions

Answer 273

Lactic acidosis

Answer 274

Saquinavir

Answer 275

Retrovir + Epivir + Kaletra

Answer 276

Ritonavir + Epivir

Answer 277

2 NNTis with an NNRTI or a Ritonavir or Integrase

Answer 278

Raltegravir + Integrase

Answer 279

They incorporate into the growing DNA and inhibit chain formation

Answer 280

Blocks protease

Answer 281

Inhibit DNA polymerase

Answer 282

Blocks entry of the virus into the cell by preventing conformational change

Answer 283

Raltegravir

Answer 284

When CD4 count is less than 200

Answer 285

In HIV patient who is pregnant

Answer 286

With Hepatits B virus coinfection

Answer 287

These are all reasons to start therapy

Answer 288

Enfuvirtide

Answer 289

Famciclovir

Answer 290

Ganciclovir

Answer 291

Raltegravir

Answer 292

Streptomycin

Answer 293

Ethambutol

Answer 294

It is not readily absorbed by the GIT

Answer 295

It is metabolized by CYP450 enzyme, therefore having many drug interactions

Answer 296

Inhibits synthesis of Mycolic acid

Answer 297

Structurally distinct from pyridoxine, therefore causing peripheral neuropathy

Answer 298

Ethambutol

Answer 299

Gives a harmless orange color to all bodilly secretions

Answer 300

Can cause cholestatic jaundice

Answer 301

Used for prophylaxis

Answer 302

Binds to bacterial RNA polymerase enzyme and inhibits RNA synthesis

Answer 303

Ethambutol

Answer 304

Streptomycin

Answer 305

Fluoroquinolones

Answer 306

Quinolones

Answer 307

Albendazole

Answer 308

Chloroquine

Answer 309

Hemolysis in G6Pd deficient individuals

Answer 310

Orange color of bodily secretions

Answer 311

Nephrotoxicity

Answer 312

Retinopathy

Answer 313

Ototoxicity

Answer 314

Irreversible neuropathy

Answer 315

Nephrotoxicity

Answer 316

Hepatitis B

Answer 317

Epstein-Barr virus

Answer 318

Chemotherapy

Answer 319

All of these are part of advanced disease treatment

Answer 320

No response with drug therapy

Answer 321

Blamed on loss of p53 tumor suppressor gene

Answer 322

Common in malignant melanoma

Answer 323

Increased expression of MDR1 gene

Answer 324

They transfer their alkyl groups to DNA within the nucleus

Answer 325

They can inhibit protein chains and DNA strand breakage by carbamoylation

Answer 326

React chemically with sulfydryl, amino,hydroxyl and phosphate groups

Answer 327

All of the above

Answer 328

Cyclophosphamide

Answer 329

Vincristine

Answer 330

Methotrexate

Answer 331

Vinblastine

Answer 332

All of the above

Answer 333

Chlorambucil

Answer 334

Vinorelbine

Answer 335

5-flurouracil

Answer 336

None of the above

Answer 337

Methotrexate

Answer 338

5-flurouracil

Answer 339

Methotrexate

Answer 340

Vinblastine

Answer 341

Cyclophospamide

Answer 342

None of the above

Answer 343

Sulfonamides

Answer 344

Trimethoprim

Answer 345

Fluoroquinolones

Answer 346

Penicillins

Answer 347

Penicillin

Answer 348

Cephalosporins

Answer 349

All of these inhibit renal excretion of methotrexate

Answer 350

Transcriptase

Answer 351

Transpeptidase

Answer 352

DNA polymerase

	Erstellt von Diana Flores vor fast 9 Jahre

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Antibiotics/Antifungals/Antivirals/Antimycobacterials/Anticancer

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