Quiz
Antibiotics/Antifungals/Antivirals/Antimycobacterials/Anticancer
Perguntas do quiz (130)
1Which of the following is a correct description of Ludwig's Angina?
- ACaused by anaerobe infection
- BIt occurs in children with concomitant dental infections
- CIt is not life-threatneing
- DCaused by infection from bacteroids, staphylococci, and streptococci
2Choose all the following that are mechanisms of select toxicity?
- AInhibition of cell wall synthesis
- BSelective Inhibition
- CSuppression of DNA synthesis
- DCommon targets
- EUnique drug targets
- FAlteration of cell membrane permeability
3Which of the following is the correct definition of Anti-infective agents?
- ANatural or synthetic substances used to suppress growth or kill bacteria/ single cell organisms
- BSubstances that act against or destroy infections (Fungal/Viral/Bacteria)
- CSubstances that destroy or supress the growth or multiplcation of bacteria
- DSubstances produced by bacteria that can destroy or suppress the growth or multiplication of bacteria or prevent the action of bacteria
4What antibacterial is given for emergency treatment of Ludwig's Angina?
- APenicillin V
- BAmpicillin
- CPenicillin G
- DAugmentin
5Which of the following is the correct mechanism for how Polymyxins act as antibiotics?
- ABinds to ribosome 30s to prohibit protein synthesis
- BDisrupts the integrity of the baceterial cell wall by displacing calcium and magnesium
- CInhibits the cross-linkages between the peptidoglycan polymer strands
- DDisrupts the integrity of the cell membrane by displacing calcium and magnesium
6Antibiotics that bind to bacterial ribosomes inhibit what enzyme?
- ATranspeptidase
- BPeptidyl transferase
- CBeta lactamase
- DTranscriptase
7How do sulfonamides prevent the further growth of bacteria?
- AThey block conversion of PABA into dihydrofolic acid
- BThey inhibit DNA gyrase and Topoismerase enzymes, preventing supercoiling
- CThey inhibit peptidyl transferase, inhibiting binding of tRNA to mRNA
- DThey bind to the dihydroflate reductase (DHFR) enzyme, thus preventing production of folic acid
8Acquired resistance is when the bacteria has always been resistant due to inherent properties of the bacteria
- AVerdadeiro
- BFalso
9Which bacteria are susceptible to enzyme inactivation by beta lactamases?
- ACephalosporins
- BMacrolides
- CMetronidazole
- DTetracyclines
10Which of the following is defines as a mobile genetic element which may be transferred from one organism to the other?
- ABacteriophages
- BIntegrons
- CTransposons
- DPlasmid
11An integron is a genetic element that captures and disseminates genes through a gene cassette
- AVerdadeiro
- BFalso
12Which of the following is NOT an example of microbial resistance?
- AEnzymatic inactvation
- BAntibiotic antagonism or interactions
- CInsensitivity to apoptosis
- DOverproduction of target sites
13Which of the following cancers do NOT have a high incidence of p53 mutations
- AOvarian
- BLung
- CColon
- DPancreatic
14Which of the following is correct regarding superinfections?
- AMore likely to occur with narrow spectrum antibiotics
- BOccurs with transfer of plasmids and transposons
- CThey are easy to treat
- DMay be opportunistic infections with viruses such as Candidda albicans and Histoplasmosis
15When would chemoprophylaxis be used?
- AUsed after surgery to prevent wound infections
- BUsed after a potential expsoure
- CTo prevent an oral infection after having a dental procedure
- DIn immunocompromised patients to prevent reactivation of latent reactions
16Penicillins are narrow spectrum drugs
- AVerdadeiro
- BFalso
17Select all of the bactericidal antibiotics
- AMacrolides
- BPencillin
- CMetronidazole
- DTetracycline
- ECefadroxil
- FCephalexin
- GAminoglycosides
- HCiprofloxacin
- IClindamycin
18Which of the following is NOT a cause for antibiotic failure?
- ALimited vascularity or blood flow to tissue
- BBlood concentration too low
- CImpaired host to immune system
- DFailure to activate the antibiotics
19Which of the following antibacterials can cause a long QT syndrome?
- AFluroquinolones
- BSulfonamides
- CPenicillins
- DCephalsporins
20Which of the following antibacterials cause agranulocytosis?
- AFluroquinolones
- BC. diff
- CMacrolides
- DPenicillins
21Which of the following is NOT a concern of antibiotic use?
- AStevens Johnsons
- BSuperinfection
- CTeratology
- DIncreased effects of oral contraceptives
22Which of the following is incorrect regarding Penicillin G/Penicillin V?
- AOne of these two can be used for treatment of Ludwig's Angina
- BUsed for mixed aerobic-anerobic infections
- CUsed for head, neck, and dental infections
- DThese are all correct
23Which of the following is the correct use of antistaphylococcal penicillins?
- ASkin and soft tissue infections
- BBroad spectrum Enterobacter
- CKlebsiella and enterocci
- DEar, nose and throat, H. pylori
24Which of the following is not an antistaphylococcal penicillin?
- AAmoxicillin
- BMethicillin
- CNafcillin
- DThese are all antistaphylococcal penicilllins
25Augmentin contains an antistaphylococcal penicillin
- AVerdadeiro
- BFalso
26Penicillins work by inhibiting which enzyme?
- AIntegrase
- BPeptidyl transferase
- CTranspeptidase
- DTranscriptase
27Penicillin V is administered IV only?
- AVerdadeiro
- BFalso
28Which of the following is NOT a possible adverse effect from peniciilins?
- AAllergy
- BFungal overgrowth
- CPseudomembraneous colitis
- DOral lesions
29Which of the following is a known drug reaction with use of penicillin?
- AIncrease renal tubular secretion with use of probenecid
- BInactivation with use of aminoglycosides
- CDisulfram-like reaction
- DInhibits metabolism of anticoagulants, increasing risk of bleeding
30Which of the following is true regarding aminopenicillins?
- AResistant to beta lactamases
- BNarrow spectrum
- CAmpicillin has less side effects than amoxicillin
- DEffective against Neissseria gonorrhea and meningitidis
31Select the following that are ineffective against beta lactamases:
- APenicillin V
- BPenicillin G
- CCloxacillin
- DAmoxicillin
32Which of the following can be used to overcome resistant bacteria?
- ACloxacillin
- BAmoxacillin
- CClavulanic acid
- DAmpicillin
33Which of the following is true regarding penicillins and beta-lactamase inhibitors?
- AAmoxicillin has a molecular structure similar to beta lactam, thus prevents inactivation by beta lactamase
- BThey are ineffective against Salmonella related infections
- CThey are used in immunocompromised patients with mixed infections
- DThey are effective against Klebsiella bacteria
34Which of the following best represents first generation cephalosporins?
- AIncludes Cefotaxime and Ceftriaxone
- BUsed for UTI and soft tissue abscesses
- CEffective against Klebsiella and H influenza
- DUsed for treatment of community-acquired pneumonia
35Which of the following best describes generation 2 cephalosporins
- ADrug of choice for surgical prophylaxis
- BUsed to treat Meningitis
- CIncludes the drug Cefuroxime
- DIncludes the drug Cefepime
36Which of the following best describes generation 3 cephalosporins?
- AThey have resistance to beta lacmases
- BHightly active against P aeruginosa
- CNot approved for treatment of meningitis
- DBest for any H influenza infection
37Which of the following best describes fourth generation cephalosporins?
- AIt is used for meningitis
- BIt includes the drug ceftaroline
- CIt is active against Neisseria
- DCan be used for MRSA
38Ceftaroline is active against MDR staph aureus, MRSA, and VRSA
- AVerdadeiro
- BFalso
39Protein synthesis inhibitors are considered narrow spectrum antibiotics
- AVerdadeiro
- BFalso
40Tetracyclines are broad spectrum antibiotics
- AVerdadeiro
- BFalso
41Which of the following best matches the mechanism of tetracyclines?
- AInhibition of beta 1-3 glycan of bacterial cell wall, preventing cross-linkages
- BBecomes mechanically reduced to a toxic metabolite, interacting with DNA
- CBinds to 50s subunit, preventing binding of tRNA to mRNA
- DBinds to 30s subunit, preventing binding of tRNA to mRNA
42Which of the following are targeted by tetracyclines
- ARickettsia
- BChlamydia
- CGram positive bacteria
- DAll are targeted by tetracyclines
43Which of the following is NOT a concern of tetracyclines?
- AKills flora
- BNeutropenia
- CImpairs absorption of antacids
- DDamages development of bones and teeth
44Which of the following is incorrect regarding macrolides?
- ABroad spectrum
- BKills Treponema pallidum
- CUsed as an alternative for patients allergic penicillins
- DCan be bacteriostatic or bacteriocidal, depending on dose
45What makes Telithromycin so special?
- AIt can be used for MRSA
- BIt can cause Fanconi's syndrome if taken when it is expired
- CIt can bind to ribosome 23s, which makes it unique
- DCan be used in cases when other macrolides cause fulminant hepatic necrosis
46Which of the following is incorrect regarding Chloramphenicol?
- AIt is bacteriostatic
- BBinds to 23s ribosome
- CCan be toxic due to inhibiting mitochondrial protein synthesis
- DCan be used for Neisseria gonorrhea
47Chloramphenicol can cause gray baby syndrome
- AVerdadeiro
- BFalso
48Which of the following is NOT a use for Clindamycin?
- APseudomembranous colitis
- BSkina nd soft tissue infections
- CSeptic abrotion
- DProphylaxis of infective endocarditis
49Which of the following is NOT a concern for use of Clindamycin?
- AFungal overgrowth
- BThrombocytopenia
- CPseudomembranous colitis
- DFulminant hepatic necrosis
50Which of the following is NOT a risk factor for pseudomembranous colitis?
- AElderly
- BSulfonamides
- CAmpicillin
- DErhythromycin
51Choose all of the following that are part of treatment of pseudomembranous colitis?
- AStart on Vancomycin IV
- BHydration
- CStart on clotrimazole
- DStart of Metronidazole
- EStop all antibiotics
- FStart on Vancomycin oral
52What is the clinical use of sulfonamides?
- ASkin infections
- BUTI
- CAlternative for patients allergic to Penicillins
- DPseudomembranous colitis
53Sulfonamide is a structural analog of DFHR
- AVerdadeiro
- BFalso
54Which of the following causes Steven-Johnson syndrome?
- ASulfonamides
- BPenicillins
- CMacrolides
- DTetracyclines
55Sulfonamides can cause which of the following adverse effects?
- ARenal damage from crystalluria
- BProlonged QT syndrome
- CPseudomembranous Colitis
- DNeutropenia
56Which of the following is NOT another name for trimethoprim?
- ACo-trimoxazole
- BBactrim
- CClotrimazole
- DSeptra
57Which best describes the mechanism of trimethoprim?
- AStructural analog of PABA
- BBinds to mammalian DHFR
- CStructural analog of bacterial DHFR
- DBinds to bacterial DHFR
58Which of the following antibiotics are best known to be used for acne?
- ATetracyclines
- BSulfonamides
- CMacrolides
- DPenicillins
59Clotrimazole can be used for UTI?
- AVerdadeiro
- BFalso
60Metronidazole is used for the treatment of amoebic liver abscesss
- AVerdadeiro
- BFalso
61How do fluoroquinolones kill bacteria?
- AThey are chemically reduced to a toxic metabolite which interacts with DNA, resulting in loss of helical structure and essentially cell death
- BThey bind to bacterial ribosomes 30s
- CThey inhibit transpeptidases
- DThey compromise the integrity of the bacterial cell membrane
62Which of the following do metronidazoles NOT attack?
- AGram positive
- BAnaerobes
- CGram negative
- DAerobes
63Which of the following is not a drug interaction of metronidazole?
- APhenytoin toxicity
- BDisulfram reactions
- CFailure of oral contraceptives
- DInhibition of anticoagulant metabolism
64Sharp metallic taste is one of many adverse effects of sulfonamides
- AVerdadeiro
- BFalso
65Which best describes the mechanism of action of fluroquinolones?
- ABinding to bacterial ribosome 50s
- BInhibits DNA gyrase, preventing supercoiling and stopping DNA replication
- CInhibits transcriptase, preventing supercoiling and stopping DNA replication
- DChemically reduced to a toxic metabolite, interacting with DNA and essentially causing cell death
66The causes of resistance in fluoroquinolones are alteration in DNA gyrase and decreased permeability
- AVerdadeiro
- BFalso
67Which of the following bacteria could cause cartilage damage in children?
- ACiprofloxacin
- BClindamycin
- CCefepime
- DAminoglycosides
68Ciprofloxacin is an extended spectrum drug
- AVerdadeiro
- BFalso
69Which of the following is true about vancomycin?
- AGiven by quick infusion for serious systemic infections
- BMay be used where resistance to macrolides has developed in bacterial strains
- CInhibits transpeptidase
- DIt is not absorbed by the GI
70Which of the following can cause Red Man Syndrome?
- APenicillin
- BErythromycin
- CVancomycin
- DSulfamethoxazole
71Which of the following is NOT true regarding aminoglycosides?
- ACan be used for the treatment of sepsis
- BSame spectrum as fluroquinolones
- CGiven only PO
- DDrug monitoring is required
72Which of the following is NOT side effect of drugs such as gentamicin, tobramycin, and amikacin?
- AReversible renal toxicity
- BIrreversible vestibular toxicity
- CNeuromuscular blockade
- DAdding furoseminde can decrease risk of renal damage
73Which of the following would you want to avoid giving prior to a surgical procedure?
- ACephalexin
- BClindamycin
- CTobramycin
74You would want to give Vancomycin PO q12h for MRSA
- AVerdadeiro
- BFalso
75VRE infects immunocompromised patients
- AVerdadeiro
- BFalso
76Which of the following cannot be used for treatment of MRSA?
- ALinezolid
- BCeftaroline
- CStreptogramins
- DVancomycin
77MRSA is resistant to ALL penicillins and cephalosporins
- AVerdadeiro
- BFalso
78What are mechanisms of genetic transfer that are related to superinfections?
- ABacteriophages
- BIntegrons
- CTransposon
- DPlasmid
79Which of the following best describes amphotericin B?
- AUsed only as topical therapy
- BDose adjustment required and dose limited to 6 months
- CA polyene antifungal that binds to ergosterol in fungal cell membranes
- DBinds to bacterial RNA polymerase enzyme and inhibits RNA synthesis
80Amphotericin B is used to only treat progressive and potentially fatal systemic infections due to its severe adverse effects
- AVerdadeiro
- BFalso
81Which of the following is NOT an adverse effect of Amphotericin B?
- AInfusion-related reactions
- BFever
- CMild elevation in liver enzymes
- DNephrotoxicity
82Which of the following does NOT increase risk of nephrotoxicity
- AAminoglycosides
- BAmphoterecin B
- CCisplatin
- DMacrolides
83Nystatin is not related to Amphoterecin B and can therefore be used systemically
- AVerdadeiro
- BFalso
84What type of fungal infection does nystatin treat?
- ACryptococcal meningitis
- BCandida infections
- CHistoplasmosis
- DAsperillosis
85What do you want to avoid taking with azole antifungals?
- AAntacids
- BEchinocandins
- CCalcium
- DMilk
86Fluconazole is a prodrug
- AVerdadeiro
- BFalso
87Choose all of the traizoles
- AKetoconazole
- BItraconazole
- CFluconazole
- DVoriconazole
- EMiconazole
- FClotrimazole
88Which is the correct mechanism of azoles?
- ADisrupts microtubule function and inhibits dermatophyte growth
- BBinds to membrane Ergosterol
- CInhibits viral DNA polymerase
- DInhibits the lanosterol 14 alpha enzyme, preventing the conversion of lanosterol to ergosterol and disrupts the struction of fungal membrane
89Which of the following is NOT an adverse effect of Azoles?
- ASteven Johnson
- BIncreased levels of warfarin
- CDecreased fluconazole levels wiht isoniazid
- DNephrotoxicity
90Which of the following are used in hematopoietic stem cell transplatation patients?
- AFluconazole
- BItraconazole
- CEchinocandins
- DIsoniazid
91Which of the following antifungals are used to disrupt microtubule function?
- ATerbinafine
- BGriseofulvin
- CEchinocandins
- DKetoconazole
92Which of the following antifungals is used for onychomychosis and tinea?
- AGriseofulvin
- BTerbinafine
- CEchinocandins
- DKetoconazole
93What is the difference between NRTIs and NNRTIs?
- ANRTIs inhibit viral DNA relication by binding to reverse transcriptase and inhibit DNA polymerase and NNRTIs act as chain terminators and imtate nucleotides
- BNNRTIs inhibit viral DNA relication by binding to reverse transcriptase and inhibit DNA polymerase and NRTIs act as chain terminators and imtate nucleotides
- CNRTIs interact with ohter drugs metabolized by CYP450 enzyme
- DNRTIs cause Stevens Johnson syndrome
94NRTIs have mitochondrial toxicity
- AVerdadeiro
- BFalso
95Which of the following is an adverse effect of NRTIs?
- ASteven Johnson Syndrome
- BCushing-like syndrome
- CLocal injection site reactions
- DLactic acidosis
96NRTIs cause Steven Johnson syndrome
- AVerdadeiro
- BFalso
97Which of the following is not a protease inhibitor?
- ASaquinavir
- BRetrovir
- CRitonavir
- DIndinavir
98Which of the following is the correct drug regimen for post-exposure prophylaxis?
- ARetrovir + Epivir + Kaletra
- BRitonavir + Epivir
- C2 NNTis with an NNRTI or a Ritonavir or Integrase
- DRaltegravir + Integrase
99How do enfuvirtides work?
- AThey incorporate into the growing DNA and inhibit chain formation
- BBlocks protease
- CInhibit DNA polymerase
- DBlocks entry of the virus into the cell by preventing conformational change
100Which of the following is an integrase inhibitor?
- ARetrovir
- BRaltegravir
- CIndinavir
- DLopinavir
101TNX-355 is used to prevent virus maturation
- AVerdadeiro
- BFalso
102When should Antiretroviral therapy be started?
- AWhen CD4 count is less than 200
- BIn HIV patient who is pregnant
- CWith Hepatits B virus coinfection
- DThese are all reasons to start therapy
103Efavirenz is the recommended drug for HIV therapy in pregnant women
- AVerdadeiro
- BFalso
104Choose the drugs that are part of HAART?
- A2NRTIs
- BNNRTIs
- CRitonavir
- DIntegrase
- EEnfuvirtide
- FBefirimat
- GTNX-355
- HAcyclovir
- IFamciclovir
105Which antiviral drug prevents formation of DNA chain by inhibiting viral DNA synthesis?
- AAcyclovir
- BGanciclovir
- CRaltegravir
- DRetrovir
106Ganciclovir causes myelosuppression
- AVerdadeiro
- BFalso
107Which of the following is used for prophylaxis of TB
- ARifampin
- BIsoniazid
- CStreptomycin
- DEthambutol
108Which of the following is true about isoniazid?
- AIt is not readily absorbed by the GIT
- BIt is metabolized by CYP450 enzyme, therefore having many drug interactions
- CInhibits synthesis of Mycolic acid
- DStructurally distinct from pyridoxine, therefore causing peripheral neuropathy
109Choose which of the following drugs are administered with isoniazid for treatment?
- ARifampin
- BEthambutol
- CRetrovir
- DAcyclovir
110Rifampin is a "true" antibiotic
- AVerdadeiro
- BFalso
111Which of the following is NOT true regarding Rifampin?
- AGives a harmless orange color to all bodilly secretions
- BCan cause cholestatic jaundice
- CUsed for prophylaxis
- DBinds to bacterial RNA polymerase enzyme and inhibits RNA synthesis
112Mr. Smith works as an airline pilot and was found to have TB. Which drug would you NOT want to give him, due to its effects on visual acuity and color discrimination?
- AIsoniazid
- BRifampin
- CEthambutol
- DStreptomycin
113Which of the following drugs is given for prophylaxis and cure of malaria?
- AFluoroquinolones
- BQuinolones
- CAlbendazole
- DChloroquine
114Which of the following are concerns with the use of Antimalarials?
- AHemolysis in G6Pd deficient individuals
- BOrange color of bodily secretions
- CNephrotoxicity
- DHepatitis
115Which of the following is NOT a concern of antimalrials with long term drug dosing?
- ARetinopathy
- BOtotoxicity
- CIrreversible neuropathy
- DNephrotoxicity
116Epstein-Barr virus can cause nasopharyngeal cancer
- AVerdadeiro
- BFalso
117Which of the following cause Hodgkins/Non-Hodgkins?
- AHepatitis B
- BHIV
- CHPV
- DEpstein-Barr virus
118Which of the following is part of treatment for advanced disease?
- ASurgery
- BRadiation
- CChemotherapy
- DAll of these are part of advanced disease treatment
119Which of the following NOT consistent with primary resistance in regards to cancer drugs?
- ANo response with drug therapy
- BBlamed on loss of p53 tumor suppressor gene
- CCommon in malignant melanoma
- DIncreased expression of MDR1 gene
120How do alkylating agents cause cell death in cancer drugs?
- AThey transfer their alkyl groups to DNA within the nucleus
- BThey can inhibit protein chains and DNA strand breakage by carbamoylation
- CReact chemically with sulfydryl, amino,hydroxyl and phosphate groups
- DAll of the above
121Which of the following causes hemorrhagic cystitis?
- ACyclophosphamide
- BCisplatin
- CVincristine
- DMitomycin
122Which of the following causes myelosuppression?
- AMethotrexate
- BVinblastine
- CMitomycin
- DAll of the above
123Which of the following cause mucositis?
- AChlorambucil
- BVinorelbine
- C5-flurouracil
- DNone of the above
124Which of the following cause neutropenia?
- AMethotrexate
- B5-flurouracil
- CMitomycin
- DCisplatin
125Which of the following causes SIADH?
- AMethotrexate
- BVinblastine
- CCyclophospamide
- DNone of the above
126Methotrexate has a similar mechanism to what other drug?
- ASulfonamides
- BTrimethoprim
- CFluoroquinolones
- DPenicillins
127Which of the following drugs does NOT inhibit renal excretion of methotrexate?
- APenicillin
- BCephalosporins
- CAspirin
- DAll of these inhibit renal excretion of methotrexate
128Imatinib prevents phosphorylation of the cell kinase substrates by ATP
- AVerdadeiro
- BFalso
129Cetuximab works against which enzyme to suppress cancer growth?
- AEGFR
- BTranscriptase
- CTranspeptidase
- DDNA polymerase
130Retinoic acid is used to treat childhood ALL
- AVerdadeiro
- BFalso
Informações
- Descrição
- Test about Antibiotics/Antifungals/Antivirals/Antimycobacterials/Anticancer
- Autor
- Diana Flores
- Idioma
- English
- Visualizações
- 180
- Etiquetas
- Avaliação
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