3140904
Frage 1
Frage
Autoimmunity is characterized by all the following except
Antworten
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It is when your immune system is acting against you
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These are acute disease with evidence of active infection
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It is due to failure of tolerance (both central and peripheral)
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none of the above
Frage 2
Frage
Negative selection in the bone marrow and thymus means removal of self reactive antigen during development
Antworten
- True
- False
Frage 3
Frage
All of the following are a feature of peripheral tolerance except?
Antworten
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No lymphocyte access to some tissues - ignorance
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Induction of anergy in autoreactive B and T cells
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Suppression of autoimmune responses by regulatory T cells - Foxp3
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Expression of tissue specific protein in thymus - Aire
Frage 4
Frage
Central deletion or inactivation of newly formed lymphocytes is the first checkpoint of self-tolerance
Antworten
- True
- False
Frage 5
Frage
Autoimmune Regulator (AIRE) is essential for acquisition of central T cell tolerance
Antworten
- True
- False
Frage 6
Frage
APECED syndrome is due to inactivating mutation of Foxp3
Antworten
- True
- False
Frage 7
Frage
all of the following are true about IPEX syndrome except
Antworten
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Autosomal dominant
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Inactivating mutation or deletion of Foxp3
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Polyendrocrinopathy
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T reg absent or non-function
Frage 8
Frage
All of the following about B cell tolerance are true except?
Antworten
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Deletion of self reactive IgM B cells in bone marrow is 100% efficient
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We all have autoreactive B cells
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Under normal circumstances a parallel autoreactive T cell will be absent and or a T reg will be present, so you are unlikely to have T cell help for autoreactive B cells
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The presence of autoreative B cell becomes obvious as one ages and loses T cell mediated regulation
Frage 9
Frage
All of the following are true about auto immune diseases except
Antworten
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MHC molecules which are able to efficiently present self antigen
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A failure to delete or functional inactivate self reactive lymphocytes - Breakdown of immunological tolerance
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Additional environmental and or genetic factors - Viral or bacterial infections, susceptibility genes, hormonal influences, toxins and tissue damage
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None of the above
Frage 10
Frage
Ankylosing spondylitis is associated with HLA B27
Antworten
- True
- False
Frage 11
Frage
People heterozygous for DQ2 and DQ8 are most susceptible to Type I Diabetes
Antworten
- True
- False
Frage 12
Frage
Sympathetic ophthalmia is an example of unveiling of antigens previously not accessible to the immune systems
Antworten
- True
- False
Frage 13
Frage
Molecular mimicry - an antibody of T cell response induced against a pathogen cross - reacts with a self antigen - ex Rheumatic fever - true of false
Antworten
- True
- False
Frage 14
Frage
An example for intermolecular epitope spreading is Pemphigus
Antworten
- True
- False
Frage 15
Frage
Over-expression of anti-inflammatory molecules and Underexpression of Pro-inflammatory molecules - is the aberrant expression seen in autoimmune diseases
Antworten
- True
- False
Frage 16
Frage
Autoimmune diseases are more common in males
Antworten
- True
- False
Frage 17
Frage
Smoking increases the autoimmune reaction by citrullinating the proteins
Antworten
- True
- False
Frage 18
Frage
Aging increases autoimmunity due to immune senescence
Antworten
- True
- False
Frage 19
Frage
All of the following about autoimmune hemolytic anemia are true except?
Antworten
-
HSR III
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Produce autoantibodies against antigens on RBCs - IgG and IgM
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It could be drug induced ex penicillin
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Diagnosis by Direct Coombs test
Frage 20
Frage
Goodpasture syndrome autoantibodies against alpha3 chain of type IV collagen in glomerular basement membrane and alveolar basement membrane
Antworten
- True
- False
Frage 21
Frage
A patient presents with multiple blisters on his back and both arms. You lightly rub his skin and another blister forms because you disrupted the connection between 200 desmosomes. All of the following are true about this disorder except?
Antworten
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HSR II
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Autoantibodies against desomogleins
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intermolecular spreading
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This condition is Pemphigus vulgaris
Frage 22
Frage
Myasthenia Gravis is due to anti-ACH receptor antibodies and Lambert-Eaton syndrome is due to auto antibodies against voltage gated Calcium channels thereby inhibiting the release of calcium
Antworten
- True
- False
Frage 23
Frage
In all II and III HSR Plasmapheresis is not effective
Antworten
- True
- False
Frage 24
Frage
All II and III HSR antibodies can cross the placenta and can effect the fetus
Antworten
- True
- False
Frage 25
Frage
All of the following are true about IDDM except
Antworten
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Peptides associated with islet cell autoantigens Glutamic acid decarboxylase 65 (GAD65) are cross reactive with Coxsackie virus proteins
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HSR III
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Macrophage activation by TNFalpha and IL-1
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Beta cell specific Th1 cells make IFNgamma
Frage 26
Frage
All of the following are true about Multiple sclerosis except?
Antworten
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Destruction of myelin sheath of nerve fibers in brain and spinal cord due to autoreactive T cells - Type IV HSR
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Areas of demyelination (plaques) seen on MRI
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Candidate antigens: Myelin basic protein and Myelin Oligodendrocyte glycoprotein
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completely curable
Frage 27
Frage
All of the following are true about SLE except?
Antworten
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Most common autoimmune rheumatic disease
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Intermolecular spreading
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HSR IV
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ANA test is a screening test only - anti-dsDNA, anti-snRNP or Sm(smith antigen) are also 100% specific for SLE
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UV-B exposure and cigarette smoking are the environmental triggers
Frage 28
Frage
All of the following are true about Rheumatoid arthritis except?
Antworten
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Presence of Rheumatoid factor is diagnostic of Rheumatoid arthritis
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Infliximab, Adalimumab, Etanercept TNFR-IG all are effective against RA
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Autoreative CD4 Tb1 cells and Tb17 cells against synovial tissue autoantigen
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None of the above
Frage 29
Frage
All of the following are true about Sjogren's syndrome except
Antworten
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Autoimmune destruction of exocrine glands
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HSR III
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Shrimer's test - to test tear production, spit test are done
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none of the above
Frage 30
Frage
All of the following are true about Wegener's Granulomatosis except
Antworten
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Anti Neutrophil Cytoplasmic antibodies (ANCA)
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Saddle nose due to destruction of the cartilage
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cavitary lesions are characteristic on chest xray
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more common in females
Frage 31
Frage
All of the following are associated with scleroderma except
Antworten
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Raynaud's syndrome
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Sclerodactyly
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Male predominance
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