Quiz
Autoimmunity
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Perguntas do quiz (31)
1Autoimmunity is characterized by all the following except
- AIt is when your immune system is acting against you
- BThese are acute disease with evidence of active infection
- CIt is due to failure of tolerance (both central and peripheral)
- Dnone of the above
2Negative selection in the bone marrow and thymus means removal of self reactive antigen during development
- AVerdadeiro
- BFalso
3All of the following are a feature of peripheral tolerance except?
- ANo lymphocyte access to some tissues - ignorance
- BInduction of anergy in autoreactive B and T cells
- CSuppression of autoimmune responses by regulatory T cells - Foxp3
- DExpression of tissue specific protein in thymus - Aire
4Central deletion or inactivation of newly formed lymphocytes is the first checkpoint of self-tolerance
- AVerdadeiro
- BFalso
5Autoimmune Regulator (AIRE) is essential for acquisition of central T cell tolerance
- AVerdadeiro
- BFalso
6APECED syndrome is due to inactivating mutation of Foxp3
- AVerdadeiro
- BFalso
7all of the following are true about IPEX syndrome except
- AAutosomal dominant
- BInactivating mutation or deletion of Foxp3
- CPolyendrocrinopathy
- DT reg absent or non-function
8All of the following about B cell tolerance are true except?
- ADeletion of self reactive IgM B cells in bone marrow is 100% efficient
- BWe all have autoreactive B cells
- CUnder normal circumstances a parallel autoreactive T cell will be absent and or a T reg will be present, so you are unlikely to have T cell help for autoreactive B cells
- DThe presence of autoreative B cell becomes obvious as one ages and loses T cell mediated regulation
9All of the following are true about auto immune diseases except
- AMHC molecules which are able to efficiently present self antigen
- BA failure to delete or functional inactivate self reactive lymphocytes - Breakdown of immunological tolerance
- CAdditional environmental and or genetic factors - Viral or bacterial infections, susceptibility genes, hormonal influences, toxins and tissue damage
- DNone of the above
10Ankylosing spondylitis is associated with HLA B27
- AVerdadeiro
- BFalso
11People heterozygous for DQ2 and DQ8 are most susceptible to Type I Diabetes
- AVerdadeiro
- BFalso
12Sympathetic ophthalmia is an example of unveiling of antigens previously not accessible to the immune systems
- AVerdadeiro
- BFalso
13Molecular mimicry - an antibody of T cell response induced against a pathogen cross - reacts with a self antigen - ex Rheumatic fever - true of false
- AVerdadeiro
- BFalso
14An example for intermolecular epitope spreading is Pemphigus
- AVerdadeiro
- BFalso
15Over-expression of anti-inflammatory molecules and Underexpression of Pro-inflammatory molecules - is the aberrant expression seen in autoimmune diseases
- AVerdadeiro
- BFalso
16Autoimmune diseases are more common in males
- AVerdadeiro
- BFalso
17Smoking increases the autoimmune reaction by citrullinating the proteins
- AVerdadeiro
- BFalso
18Aging increases autoimmunity due to immune senescence
- AVerdadeiro
- BFalso
19All of the following about autoimmune hemolytic anemia are true except?
- AHSR III
- BProduce autoantibodies against antigens on RBCs - IgG and IgM
- CIt could be drug induced ex penicillin
- DDiagnosis by Direct Coombs test
20Goodpasture syndrome autoantibodies against alpha3 chain of type IV collagen in glomerular basement membrane and alveolar basement membrane
- AVerdadeiro
- BFalso
21A patient presents with multiple blisters on his back and both arms. You lightly rub his skin and another blister forms because you disrupted the connection between 200 desmosomes. All of the following are true about this disorder except?
- AHSR II
- BAutoantibodies against desomogleins
- Cintermolecular spreading
- DThis condition is Pemphigus vulgaris
22Myasthenia Gravis is due to anti-ACH receptor antibodies and Lambert-Eaton syndrome is due to auto antibodies against voltage gated Calcium channels thereby inhibiting the release of calcium
- AVerdadeiro
- BFalso
23In all II and III HSR Plasmapheresis is not effective
- AVerdadeiro
- BFalso
24All II and III HSR antibodies can cross the placenta and can effect the fetus
- AVerdadeiro
- BFalso
25All of the following are true about IDDM except
- APeptides associated with islet cell autoantigens Glutamic acid decarboxylase 65 (GAD65) are cross reactive with Coxsackie virus proteins
- BHSR III
- CMacrophage activation by TNFalpha and IL-1
- DBeta cell specific Th1 cells make IFNgamma
26All of the following are true about Multiple sclerosis except?
- ADestruction of myelin sheath of nerve fibers in brain and spinal cord due to autoreactive T cells - Type IV HSR
- BAreas of demyelination (plaques) seen on MRI
- CCandidate antigens: Myelin basic protein and Myelin Oligodendrocyte glycoprotein
- Dcompletely curable
27All of the following are true about SLE except?
- AMost common autoimmune rheumatic disease
- BIntermolecular spreading
- CHSR IV
- DANA test is a screening test only - anti-dsDNA, anti-snRNP or Sm(smith antigen) are also 100% specific for SLE
- EUV-B exposure and cigarette smoking are the environmental triggers
28All of the following are true about Rheumatoid arthritis except?
- APresence of Rheumatoid factor is diagnostic of Rheumatoid arthritis
- BInfliximab, Adalimumab, Etanercept TNFR-IG all are effective against RA
- CAutoreative CD4 Tb1 cells and Tb17 cells against synovial tissue autoantigen
- DNone of the above
29All of the following are true about Sjogren's syndrome except
- AAutoimmune destruction of exocrine glands
- BHSR III
- CShrimer's test - to test tear production, spit test are done
- Dnone of the above
30All of the following are true about Wegener's Granulomatosis except
- AAnti Neutrophil Cytoplasmic antibodies (ANCA)
- BSaddle nose due to destruction of the cartilage
- Ccavitary lesions are characteristic on chest xray
- Dmore common in females
31All of the following are associated with scleroderma except
- ARaynaud's syndrome
- BSclerodactyly
- CMale predominance
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