323663
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
Which Gprotein causes the activation Phospholipase CBeta?
Antworten
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Gq
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Gs
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Gi
Frage 2
Frage
How is Phospholipase CBeta activated?
Antworten
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By GTP binding to the alpha subunit of the Gq protein
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By ATP binding to the alpha subunit of the Gq protein
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By GMP binding to the alpha subunit of the Gq protein
Frage 3
Frage
What is broken down by phospholipase CBeta?
Antworten
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Phosphatidynositol 4,5 bisphophate
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Phosphatidynositol 3,5 bisphophate
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Phosphatidynositol 2,4 bisphophate
Frage 4
Frage
Which product of the PCbeta pathway causes the release of calcium from the ER?
Antworten
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IP3
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Diacylglycerol
Frage 5
Frage
What role(s) does the released Ca perform?
Antworten
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Activates protein kinase C
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Activates protein kinase B
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Activates various Ca dependent protein kinases
Frage 6
Frage
What residues are phosphorylated by the protein kinases activated by this pathway?
Antworten
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Serine
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Threonine
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Tyrosine
Frage 7
Frage
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Antworten
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PS
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C1A
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C4
Frage 8
Frage
What is the function of subunut C1A
Antworten
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DAG binding site
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Calcium binding site
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Phosphatidyl serine binding site
Frage 9
Frage
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Antworten
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Yes
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No
Frage 10
Frage
Which subunits are part of the catalytic domain?
Antworten
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C1A
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C3
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C4
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PS
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C5
Frage 11
Frage
ATP binds to C2, True or False?
Antworten
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True
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False
Frage 12
Frage
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Antworten
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It moves to the membrane and binds with DAG
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It remains in the cytoplasm and binds with DAG
Frage 13
Frage
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Antworten
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Phosphatidylserine
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Phosphatidylglycine
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Phosphatidylglutamate
Frage 14
Frage
Which of the following is a tumor promoting agent?
Antworten
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Phorbol ester
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Orphol ester
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Phenyl ester
Frage 15
Frage
How do tumor promoting agents effect Phospholipase CBeta?
Antworten
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They bind without being degraded, so it becomes hyperactive
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They stop the alpha subunit binding, so it becomes unreactive
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They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity
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