Quiz
cGMP Stimulated Protein Kinase & NO Synthase
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Questions in this quiz (18)
1What is so special about cGMPPK?
- AIt's anti-parallel
- BThe subunits of the dimer can swap roles of damage occurs
- CIt's only found in cardiac cells
2How many cGMP bind per monomer?
- A2
- B4
- C6
- D1
- E3
3Which order do the subunits go in (from N to C terminus)
A= Dimerisation Domain
B- Catalytic Domain
C= Autoinhibitory Hinge Region
D= cGMP binding sites 1 & 2- AA-C-D-B
- BA-B-D-C
- CC-A-D-B
- DC-D-A-B
4What is the purpose of the autoinhibitory hinge region?
- AActs as a pseudosubstrate
- BCauses inhibition after a certain amount of activity
5What motif does cGMP Stimulated Protein Kinase Phosphorylate?
- AArg-Ser-X-Arg
- BArg-Thr-X-Arg
- CArg-Arg-X-Ser
- DArg-Arg-X-Thr
6What is the role of this protein?
- AThe activation of cGMP dependent ion channels
- BActivates cGMP dependent phosphodiesterases
- CThe activation of cGMP dependent proteins
- DInhibits cGMP dependent phosphodiesterases
7What is required for NO to be synthesized?
- ANO synthase
- BFMD/FAD
- CO2
- DNADP
- ENADPH
- FFMD
- GTetrahydrobiopterin
8Which of the following stimulate NO production?
A- AcH
B- Bradylunin
C- Nicotine
D- Thrombin
E- Cl-
F- Ca2+- AA, B, D, F
- BA, D, E, F
- CB, C, D, F
9Which system is NO part of?
- AParacrine
- BJuxtracrine
- CAutocrine
- DEndocrine
10NO is synthase a monomer- True or False?
- ATrue
- BFalse
11How many types of NO synthase are there?
- AConstitutive
- BInducible
- CConstitutive & Inudcible
12Why is NO produced by iNOS (Immune NO Synthase)
- AIt kills of pathogens
- BIt's used to signal immune cells
- CIt's used to bind and immobalise pathogens
13NO Synthase produces a few mmol of NO over a minute- True or False?
- ATrue
- BFalse- its pmol over a minute
- CFalse, it's micromol in a few seconds
- DFalse, its pmol over a few seconds
14NO Synthase contains the following, but in which order?
A-NADPH binding site
B-Calmodulin Binding Site
C-FMN centre
D- FAD centre
E-Haeme group
F- Arg, O2 and Tetrahydropterin (Active site)- AE-F-B-C-D-A
- BA-D-B-C-F-E
- CE-F-A-C-D-B
15Why are vascular endothelial cells equipped to cause vasodilation?
- AIt allows them to reduce blood pressure according to need
- BIt allows them to increase blood flow to wounded areas
- CIt prevents damage to veins under high pressure
16Which neurotransmitter effects which cells?
A- Ach
B-Vasopressin- AVascular Endothelial-A
Skeletal Muscle-B - BVascular Endothelial- A&B
Skeletal Muscle-A - CVascular Endothelial- A
Skeletal Muscle-A&B
- AVascular Endothelial-A
17What is the role of nitroglycerin?
- AAn explosive
- BIt liberates NO from tissues
- CCauses an increase in NO synthesis
18What is the role of viagra?
- AInhibits phosphodiesterases
- BPrevents cGMP breakdown
- CProlongs NO production
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- Description
- Year 2 Quiz on cGMP Stimulated Protein Kinase & NO Synthase, created by gina_evans0312 on 03/11/2013.
- Author
- gina_evans0312
- Language
- English
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