323913
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
What is so special about cGMPPK?
Answer
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It's anti-parallel
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The subunits of the dimer can swap roles of damage occurs
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It's only found in cardiac cells
Question 2
Question
How many cGMP bind per monomer?
Answer
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2
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4
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6
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1
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3
Question 3
Question
Which order do the subunits go in (from N to C terminus)
A= Dimerisation Domain
B- Catalytic Domain
C= Autoinhibitory Hinge Region
D= cGMP binding sites 1 & 2
Answer
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A-C-D-B
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A-B-D-C
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C-A-D-B
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C-D-A-B
Question 4
Question
What is the purpose of the autoinhibitory hinge region?
Answer
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Acts as a pseudosubstrate
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Causes inhibition after a certain amount of activity
Question 5
Question
What motif does cGMP Stimulated Protein Kinase Phosphorylate?
Answer
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Arg-Ser-X-Arg
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Arg-Thr-X-Arg
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Arg-Arg-X-Ser
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Arg-Arg-X-Thr
Question 6
Question
What is the role of this protein?
Answer
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The activation of cGMP dependent ion channels
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Activates cGMP dependent phosphodiesterases
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The activation of cGMP dependent proteins
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Inhibits cGMP dependent phosphodiesterases
Question 7
Question
What is required for NO to be synthesized?
Answer
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NO synthase
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FMD/FAD
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O2
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NADP
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NADPH
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FMD
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Tetrahydrobiopterin
Question 8
Question
Which of the following stimulate NO production?
A- AcH
B- Bradylunin
C- Nicotine
D- Thrombin
E- Cl-
F- Ca2+
Answer
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A, B, D, F
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A, D, E, F
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B, C, D, F
Question 9
Question
Which system is NO part of?
Answer
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Paracrine
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Juxtracrine
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Autocrine
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Endocrine
Question 10
Question
NO is synthase a monomer- True or False?
Answer
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True
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False
Question 11
Question
How many types of NO synthase are there?
Answer
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Constitutive
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Inducible
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Constitutive & Inudcible
Question 12
Question
Why is NO produced by iNOS (Immune NO Synthase)
Answer
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It kills of pathogens
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It's used to signal immune cells
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It's used to bind and immobalise pathogens
Question 13
Question
NO Synthase produces a few mmol of NO over a minute- True or False?
Answer
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True
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False- its pmol over a minute
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False, it's micromol in a few seconds
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False, its pmol over a few seconds
Question 14
Question
NO Synthase contains the following, but in which order?
A-NADPH binding site
B-Calmodulin Binding Site
C-FMN centre
D- FAD centre
E-Haeme group
F- Arg, O2 and Tetrahydropterin (Active site)
Answer
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E-F-B-C-D-A
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A-D-B-C-F-E
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E-F-A-C-D-B
Question 15
Question
Why are vascular endothelial cells equipped to cause vasodilation?
Answer
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It allows them to reduce blood pressure according to need
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It allows them to increase blood flow to wounded areas
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It prevents damage to veins under high pressure
Question 16
Question
Which neurotransmitter effects which cells?
A- Ach
B-Vasopressin
Answer
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Vascular Endothelial-A Skeletal Muscle-B
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Vascular Endothelial- A&B Skeletal Muscle-A
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Vascular Endothelial- A Skeletal Muscle-A&B
Question 17
Question
What is the role of nitroglycerin?
Answer
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An explosive
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It liberates NO from tissues
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Causes an increase in NO synthesis
Question 18
Question
What is the role of viagra?
Answer
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Inhibits phosphodiesterases
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Prevents cGMP breakdown
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Prolongs NO production
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