Flashcards
Toxicology
Cards in this deck (18)
- 1Gastric Evacuation drugs3% hydrogen peroxide
Syrup of Ipecac
Xylazine
Apomorphine - 2Describe gastric lavagelight anasthesia/cuffed ET tube
tepid tap water/saline
gravity flow to aspirate
repeat until clear - 3Adsorbents examplesActivated charcoal
Fullers Earth - 4How to enhance elimination via urinary tractAcidify - ammonium chloride
alkinisation - sodium bicarbonate - 5Chocolate toxicitytheobromine
Cs - vomiting, excitability, ataxia, tachycardia
Tx - decontamination and symptomatic - 6Ethylene glycoltoxic metabolites
CS - early weakness, vomiting, incoordination
delayed - thirst, anaemia, convulsions, death
Tx - 20%ethanol with 5% sodium bicarbonate - 7OrganophosphatesInhibit acetylcholinesterase via muscarinic receptors
CS - parasympathetic and NM activity
DUMBLES
Tx - atropine muscarinic antagonist
oxines - reactivate acetylcholinesterases by removing organsophsophates - 8Arsenic/MercuryGeneral tissue poison - inaction of enzymes including sulphydyl groups and oxidative phosphorylation
CS - acute - alimentary tract
chronic - nervous system
Tx - GI decontamination, chelating agents - 9Psychoactive drugsRapid CNS effects
Tx - decontamination, sympathetic, specific antagonists - 10ParacetamolCats deficient in glucuronyl transferase -required for conjugation
oxidises Hb to metHb
CS -facial oedema, cyanosis, liver damage, jaundice
Tx - decontamination, N-acetylcysteine, sodium sulphate, vit C, methylene blue - 11Anticoagulant rodenticidesvitamin K antagonist - interferes with production of clotting factors
CS - depression, anorexia, at high doses - vascular collapse
Tx - vit K - 12Common Ragwortpyrrolizidine alkoloids
CS - cattle - poor appetitie, constipation/diarrhoea, jaundice, head pressing
horses - lethargy, yawning, blindness
Tx - remove from pastures - 13Brackenthiaminase breakdown vit b12
carcinogens
cyanogenic glycosides
CS - BM depression, thiamine deficiency , bladder and GIT tumours
Tx - supportive and blood tranfusion
thiamine supplement - 14Yewtoxins - Taxines, inhibit sodium and calcium currents
CS - V and D, hypersalivation, hypothermia, bradycardia, resp depression, convulsions, sudden death
No antidotes - 15OakTannins - poisonous compounds
CS - kidney damage, gastroenteritis, appetite depression, blood in urine, colic
No antedote - 16Onion and Garlicoxidant toxins contain thiosulphate
Cats and dogs don't have enzyme to digest
CS - weakness, V and D, breathlessness, blood in urine
lag time to symptoms 2 days - 17Grapes, raisins etcMOA unclear
large individual variation - 18LiliesCats
calcium oxalate and oxalic acid crystals
irritate MM as crystals are sharp
CS - hypersalivation , v and d, anorexia
3-6 hours
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- Flashcards on Toxicology, created by Agatha Lowe on 13/12/2014.
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- Agatha Lowe
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