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Axon guidance
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Axon guidance
Weiss hypothesis- random outgrowth and elimination of non-functional
Sperry hypothesis- specific outgrowth due to chemoaffinity
- usually posterior retina to anterior tectum, vice versa
- experiments where posterior (temporal) retina removed, anterior (nasal) grew directly to posterior tectum
- REGENERATION NOT DEVELOPMENT!
- experiments where posterior (temporal) retina removed, anterior (nasal) grew directly to posterior tectum
- usually posterior retina to anterior tectum, vice versa
DEVELOPMENT!
- Highly stereotyped, find way to target due to guidance cues
- Pioneering axons, pathway for developing axons to follow
- If removed then axon growth stunted despite presence of other axons
- Therefore releases specific cues!!!
- LABELLED_PATHWAY HYPOTHESIS
- selective fasciculation of axons with other axons
- LABELLED_PATHWAY HYPOTHESIS
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- Mind Map on Axon guidance, created by ally2981 on 22/01/2015.
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- ally2981
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