Research

Research

1. Tinzaparin (INNOHEP)

   • LMWH inhibits factor Xa by enhancingthe action of antithrombin III. Factor Xa activates prothrombinase which transforms prothrombin-thrombin and fibrinogen-fibrin.
   • Clear, colorless, to slightly yellow. Inspect for particulate matter and discoloration.
   • Route: SC, supine or sitting
   • Tuberculin syringe or prepackage syringe
   • The administration of LMWH
     • Injection, left or right abdomen, 5cm from umbillicus.
     • Give insulin in prefilled syringe, don't expel air bubble.
     • Skin fold held between thumb and forefinger, skin fold held throughout injection. DON't rub injection site to minimize bruising.
     • Asse site for pain, bruising, bleeding...
   • Monitor for bleeding, don't give with other medications that have anticoagulant effects (aspirin, NSAIDs), monitor for hypersensitivity, lab values
   • Spironolactone
     • Potassium sparing diuretic, aldosterone antagonist
       • S/E: hyperkalmeia
         • Active metabolite, long t1/2

2. ADVAIR

   • Prime : 4 sprays into the air away from the face, shake for 5 seconds before each spray. Not used for more than 4 weeks or when it has been dropped, prime inhaler releasing 2 sprays into the air away from the face, shaking 5 seconds before each spray

3. ASA (aspirin)

   • Block thromboxane A2 to prevent platelet aggregation
   • NSAID and Antiplatelet
     • S/e: nausea,vomiting, gastric ulcers, hemorrhage

4. Atorvastatin (Zocor)

   • HMG-CoA reductase inhibitor in the liver, by blocking it decrease LDL synthesis. 1st line tx for lipid disorders.
   • s/e: myopathy, CYP interactions (not with grapefruit juice, niacin, fibrates

5. Escitalopram (Lexapro)

   • SSRI- antidepressant
   • Cation with CNS drugs

6. Lansoprazole (Prevacid)

   • PPI- tx of ulcer, delayed release capsules?

7. Lasix (Furosemide)

   • Loop diuretic
     • Block: sodium, chloride and potassium
     • S/E: hypokalemia, hypovolemia
   • IV, PO
     • High PPB
       • Ototoxicity

8. Metoprolol

   • BB (B1 in high doses B2)
     • Vaso/broncoconstriction
     • Decrease HR, contractility, rate AV conduction
     • S/E: lethargy, GI disturbances (diarrhea), HF, depression, decrease BP

9. Percocet

   • Oxycodone-acetaminophen

10. Levothyroxine (Synthroid)

    • can cause constipation in low doses and diarrhea in high doses