Rheumatoid Arthritis and Diet

Rheumatoid Arthritis and Diet

1. Traditional remedies

   • Ancient Greece
     • Bee stings
   • Folk
     • Mustard seed
     • Cedarwood oil
     • Aloe vera
     • Frankincense
     • Bee/ant stings (formic acid)
   • Ayurveda ("ama vat")
     • Herbal medicine
   • Chinese ("bi syndrome")
     • Acupuncture, herbal medicine
   • Ancient Rome
     • Garum, fish paste
   • 19th Century
     • Light nutritious diet, tonics

2. Dietary interventions

   • Mediterranean
   • Vegetarian
   • Fasting
   • Anti-inflammatory
     • High omega 3s
     • Supplementation, eg. tumeric
     • Probiotics
   • Vegan
   • Gluten free

3. Disease characteristics

   • Incidence
     • Geography
     • Sex
     • Numbers affected
     • Age
   • Symptoms
     • Joint pain
     • Joint stiffness
     • Loss of motion
     • Joint swelling
     • Fatigue
     • Joint tenderness
   • Types
     • Monocyclic
     • Polycyclic
     • Progressive

4. Measuring disease activity

   • How
     • Patient questionaire
     • X-ray, CRI, ultrasound
     • Joint counts (disease activity score) - DAS28
     • Blood test, urine sample test
     • Physical examination
     • Function test, eg. grip test, walking
   • What
     • Disease Activity
       • Urinary peptide markers
       • Cytokines
       • MiRNA (synovial fluid)
       • Inflammation - CRP, ESR
     • Functional impairment
     • Physical damage

5. Current scientific evidence

   • RCTs
   • Meta-analysis
   • Systematic review
   • Case studies
   • Cohort studies
   • Current limitations
     • Small studies
     • Mostly observational

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