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PHSI3012 04-2 Leukaemia
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Questions in this quiz (20)
1The vast majority of cancers are:
- AMonoclonal
- BPolyclonal
2Etymology.
The "Leuk-" part of leukaemia means what?- ABlood
- BWhite
- CCancer
3Etymology.
The "-aemia" part of leukaemia means what?- ABlood
- BWhite
- CCancer
4Most cancers are derived from what type of cells?
- AEpithelial
- BMesenchymal
5Blood cell malignancies.
The most obvious difference between Leukaemia and Lymphoma is what?- ALeukaemia is mainly in circulation.
Lymphoma is mainly in lymph nodes (or spleen). - BLeukaemia is mainly in lymph nodes (or spleen).
Lymphoma is mainly in circulation. - CNo noticeable differences.
- ALeukaemia is mainly in circulation.
6Roughly what proportion of the cells in your body are blood cells?
- A1 / 2
- B1 / 4
- C1 / 8
- D1 / 16
- E1 / 32
- F1 / 64
7What is the etymology of Macrophages?
(which are a subcategory of Leukocytes)- AMacro- = "Big"
-phage = "Eater" - BMacro- = "Little"
-phage = "Eater" - CMacro- = "Big"
-phage = "Enzyme" - DMacro- = "Little"
-phage = "Enzyme"
- AMacro- = "Big"
8Etymology.
Blast cells. What does "Blast" mean in Greek?- ABud
- BDestroyer
- CEater
- DBuilder
9What are the distinguishing features of Blast Cells?
(select all that apply)- AHaematopoietic progenitor cells
- BHighly proliferative
- CLarge, transcriptionally active nucleus
- DSurvival and proliferation dependent on Growth Factor signalling
- EHepatopoietic progenitor cells
- FFully mature cells
- GNormally found in large quantities in blood vessels
10True or false?
Mature blood cells typically have more active nuclei than blasts.- ATrue
- BFalse
11True or false?
-blasts are the most likely cell type to become Leukaemic.- ATrue
- BFalse
12True or false?
-blasts are the least likely cell type to become Leukaemic.- ATrue
- BFalse
13True or false?
Mature blood cells typically have less active nuclei than blasts.- ATrue
- BFalse
14There are 4 types of Leukaemia. These include:
(select all that apply)- AALL - Acute Lymphoblastic Leukaemia
- BAML - Acute Myelogenous Leukaemia
- CCLL - Chronic Lymphoblastic Leukaemia
- DCML - Chronic Myelogenous Leukaemia
- EALL - Acute Lymphatic Leukaemia
- FAML - Acute Myelodysplastic Leukaemia
- GCLL - Chronic Lymphatic Leukaemia
- HCML - Chronic Myelodysplastic Leukaemia
15Acute Leukaemias arise from [blank_start]__________[blank_end] .
Chronic Leukaemias arise from [blank_start]__________[blank_end] .- AStem Cells
- BCommitted Precursors
- CLate Precursors and Mature Forms
- DStem Cells
- ECommitted Precursors
- FLate Precursors and Mature Forms
16There are 3 ways to donate marrow.
1 - Bone marrow transplant (becoming less common, though)
2 - PBSC
3 - Cord Blood (saved since birth)
PBSC stands for [blank_start]__________[blank_end] Blood Stem Cell- APurified
- BPeripheral
- CProgenitor
- DPlease don't fuck this up
17The Philadelphia chromosome (AKA Bcr-Abl) is a translocation between chromosomes 9 and 22 that results in a fusion protein called "BCR-ABL". What is the effect of this?
- ABlocks myeloid differentiation in the progenitor stage
- BBlocks myeloid differentiation in the haematopoietic stem cell stage
- CBlocks lymphoid differentiation in the progenitor stage
- DBlocks lymphoid differentiation in the haematopoietic stem cell stage
18Bcr-Abl.
Bcr = Breakpoint Cluster Region protein
Abl = Abelson Murine Leukaemia viral oncogene homolog 1 (a non-receptor tyrosine kinase)
The fusion of the two results in what?- AConstitutive activation of the Abl kinase
- BInactivation of the Abl kinase
19Lymphoma is a malignancy arising from which of the following?
- AProgenitor B and T cells in the peripheral lymphoid tissues
- BProgenitor B and T cells in the bloodstream
- CErythrocytes in the bloodstream
- DLeukocytes in the bloodstream
20Which of the following are symptoms of Leukaemia?
(select all that apply)- AHyperviscosity syndrome
- BBruising
- CAnaemia
- DArthritis
- ESplenomegaly
- FAbnormal blood cell profiles (more nucleated cells in the blood)
- GAbnormal blood cell profiles (fewer nucleated cells in the blood
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- User has deleted their subject information Quiz on PHSI3012 04-2 Leukaemia, created by Deleted user on 18/11/2017.
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- Created on 18 Nov 2017 · updated on 18 Nov 2017
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