Quiz
PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)
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Questions in this quiz (8)
1Cholesterol is a 26-Carbon sterol lipid that’s synthesised through a complex 37-step process.
It composes [blank_start]__________[blank_end] of cell membranes.
Circulating cholesterol arises from the diet as well as from [blank_start]__________[blank_end] synthesis.
It circulates mostly as Cholesterol Ester (cholesterol + FA).- A10%
- B30%
- C50%
- D70%
- E90%
- FIntracellular
- GExtracellular
- HIntercellular
2Familial Hypercholesterolaemia is a family of pathologies that range from heterozygous to homozygous. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] levels. Caused by a loss of LDL-R.
- AIncreased
- BDecreased
- CLDL-Chol
- DHDL-Chol
3Lysosomal Storage Disease (aka Niemann-Pick disease type C) is a collection of ~50 rare inherited metabolic pathologies. Its hallmark is defective lysosomal function. It’s characterised by [blank_start]__________[blank_end] [blank_start]__________[blank_end] in the lysosome due to the loss of function of NPC1 and/or NPC2.
- AFree cholesterol
- BFFA
- CTAG
- DAccumulation
- EDissipation
4The highly proliferative nature of cancer cells means they have increased metabolic requirements, especially of which two things?
- AEnergy
- BPhospholipids
5In cancer, metabolism changes.
De Novo Cholesterol [blank_start]__________[blank_end] [blank_start]__________[blank_end];
De Novo Lipid [blank_start]__________[blank_end] [blank_start]__________[blank_end].- ASynthesis AND uptake
- BSynthesis
- CUptake
- DIncreases
- EDecreases
- FIncreases
- GDecreases
- HSynthesis AND uptake
- ISynthesis
- JUptake
6Prostate cancer growth is [primarily?] driven by [blank_start]__________[blank_end].
It’s a [blank_start]__________[blank_end] metabolism cancer and is greatly dependent on [blank_start]__________[blank_end].- AAndrogens
- BNon-Warburg
- CWarburg
- DFatty Acid oxidation
- EReactive Oxygen Species
- FCholesterol oxidation
7CRPC = ??
- ACastration-Resistant Prostate Cancer
- BCastratian-Resistant Prostate Cancer
8Gene Expression of Steroidogenic Enzymes is [blank_start]__________[blank_end] in CRPC.
- AIncreased
- BDecreased
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- PHSI3012 10-2 Disorders of Lipid Metabolism #2 (T3L2)
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- Created on 24 Nov 2017 · updated on 24 Nov 2017
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