Definitions

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Lecture 1

Paracelsus (1493–1541) Poison is in everything

Is defined as what the body does to the drug (ADME processes)

ADME processes occur simultaneously

Significance of PK

Dose and Rate

Individualizing Therapy

Dosage adjustment for drugs

How food affects

optimize compliance

Math

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Lecture 2

Ln (N) = 2.303 Log (N)

To linearize it, we convert the concentration (y-axis) to logarithm scale while the time (x-axis) remains as is– called semilog scale

Zero Order - line; constant slope

First Order - log

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Lecture 4