473842
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
The vascular endothelium protects platelets from subendothelial aggregating substances i.e. collagen
Respuesta
- True
- False
Pregunta 2
Pregunta
Vasoconstriction around injured site helps coagulation how?
Respuesta
-
Reduced blood flow decreases pressure and loss of blood
-
Reduced blood flow brings coagulation factors into tissue contact more readily
-
Reduced blood flow decreases wall diameter, decreasing size of breach
Pregunta 3
Pregunta
Why is Fibrinolysis necessary?
Respuesta
-
It prevents inappropriate extension of the fibrin plug
-
Prevents clotting from damaging nearby cell
-
Prevents clotting in case of infected blood
Pregunta 4
Pregunta
To prevent inappropriate prevention of coagulation, where are coagulation inhibitors limited to?
Respuesta
-
Intact endothelium
-
Breached endothelium
-
Free flowing blood
Pregunta 5
Pregunta
Inhibitors are triggered by late products of coagulation
Respuesta
- True
- False
Pregunta 6
Pregunta
What is inhibited by the Tissue Factor Pathway Inhibitor?
Respuesta
-
FX reversibly
-
FX permanently
-
FVII
-
FV
Pregunta 7
Pregunta
Anthithrombin deactivates several enzymes of the coagulation system
Respuesta
- True
- False
Pregunta 8
Pregunta
Protein S & C work the same way
Respuesta
- True
- False
Pregunta 9
Pregunta
The Protein C pathway is initiated by what?
Respuesta
-
Thrombin
-
Antithrombomodulin
-
Antithrombin
Pregunta 10
Pregunta
Thrombomodulin works in the free flowing blood
Respuesta
- True
- False
Pregunta 11
Pregunta
Both thrombin and thrombomodulin work on the endothelial cell surface
Respuesta
- True
- False
Pregunta 12
Pregunta
What is the role of thrombomodulin?
Respuesta
-
Conversion of Thrombin to Antithrombin
-
Conversion of Thrombin to a Coagulation Inhibitor
-
Removal of platelets
Pregunta 13
Pregunta
Excess thrombin binds to thrombomodulin on intact cells, which allows it to be altered
Respuesta
- True
- False
Pregunta 14
Pregunta
Protein C acts as an anticoagulant by degrading Factors
Respuesta
-
V
-
VIII
Pregunta 15
Pregunta
Protein C needs Mg in order to function
Respuesta
- True
- False
Pregunta 16
Pregunta
Which of the following support Protein C activity?
Respuesta
-
Protein S
-
Inactive F V
-
Active F V
Pregunta 17
Pregunta
60% of patients with thrombophilia have a
Respuesta
-
Factor II deficiency
-
Protein C deficiency
-
Protein S deficiency
Pregunta 18
Pregunta
VTE = Venous Thromboembolism
Respuesta
- True
- False
Pregunta 19
Pregunta
What is thrombosis?
Respuesta
-
An increased liklihood of spontaneous clotting
-
An inability to form blood clots
Pregunta 20
Pregunta
Name the risk factors for thrombophilia
Respuesta
-
Alteration in blood components i.e. pregnancy
-
Circulatory stasis i.e. venous problems
-
Artificial surfaces i.e. a STENT
Pregunta 21
Pregunta
VTE occurs when blood coagulation overwhelms fibrogenlysis/anticoagulant mechanisms
Respuesta
- True
- False
Pregunta 22
Pregunta
Thrombophilia is linked to Lupus Anticoagulant Syndrome
Respuesta
- True
- False
Pregunta 23
Pregunta
Name some examples where Anticoagulation therapy is necessarry
Respuesta
-
Patient with a myocardial infarction (MI)
-
Patients with Lupus/APS
-
Deep Vein Thrombosis/ Primary Embolism
Pregunta 24
Pregunta
How is Heparin administered?
Respuesta
-
Intravenously
-
Subcutaneously
-
Ingestion
Pregunta 25
Pregunta
How does Heparin work?
Respuesta
-
Increases action of Antithrombin
-
Increases Protein C activity
-
Increases degredation of platelets
Pregunta 26
Pregunta
Why is Low Molecular Weight Heparin better?
Respuesta
-
100% bioavalibility
-
Longer half life
-
Less frequent osteoporosis
Pregunta 27
Pregunta
Dabigatran is only used in cases of Atrial Fibrilation
Respuesta
- True
- False
Pregunta 28
Pregunta
Dabigatran is a FX inhibitor, Rivaroxabin is a thrombin inhibitor
Respuesta
- True
- False
Pregunta 29
Pregunta
Warfarin works how?
Respuesta
-
Directly inhibits thrombin
-
Inhibits Vit K metabolism
-
Lyses platelets
Pregunta 30
Pregunta
Without Vitamin K, why is coagulation so much slower?
Respuesta
-
Non carboxylated factors cannot bind to Ca2+
-
Non carboxylated factors cannot bind to phosphorylated
-
Non carboxylated factors cannot be inhibited
Pregunta 31
Pregunta
Warfarin is used when all four clotting factors are low
Respuesta
- True
- False
Pregunta 32
Pregunta
What is the leading dose of Warfarin?
Respuesta
-
6mg for 3 days
-
3mg for 6 days
Pregunta 33
Pregunta
What test is used to monitor warfarin activity?
Respuesta
-
Prethrombin time
-
Activated Partial Thromboplastin Time
-
Fibrin Assay
Pregunta 34
Pregunta
What is the reference for Prethrombin Time?
Respuesta
-
Standard reference thromboplastin
-
Potency is ISI- International Sensitivity Index
-
Standard reference antithrombin
Pregunta 35
Pregunta
INR = Prethrombin Time/ Mean Normal Prethrombin Time
Respuesta
- True
- False
Pregunta 36
Pregunta
Match the dangerous INR ranges-
A= (2-3)
B= (3-4)
Respuesta
-
A= Prosthetic Heart Valves B = DVT
-
A = DVT B = Prosthetic Heart Valves
Pregunta 37
Pregunta
When using Warfarin, stop if the INR <2 for two consecutive days
Respuesta
- True
- False
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