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Protein diversity
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- 1How can mutations cause mistakes in proteins?Mutations cause a change in the base sequence of a gene
This can then cause a change in the amino acid sequence of the protein it codes for.
This changes the properties of the protein - 2Give an example of why mutated proteins might be of particular interest for public healthA mutation in DNA gyrase can lead to bacterial resistance to quinolones (a class of antibiotics)
- 3How can deliberate mutation of the amino acid sequence of proteins help us study them?- is protein activated by phosphorylation of serine?
- 2 proteins one on, one off
- negative control serine->alanine
- positive control serine -> glutamate
If pos. functions and neg. doesn't then reject null - 4Describe the structure of actin and its functionCan be in globular or filament structure
4 different domains
Found in the cytoskeleton - 5Describe how the structure of an embedded potassium channel allows it to act as a selective filterNarrow channel = no big proteins (3A)
Water filled channel = no uncharged ions
Neg. charged a.as at binding site = only positively charged ions - 6Explain how DNA binding proteins recognise DNA- alpha helix in one homeodomain inserts into DNA major groove
- Recognises edges of bases NOT PAIRS - 7Describe the structure of antibodies and how this helps agglutination- B-sheet dominant
- three domains (2xFab, 1xFac)
Two antibody binding sites allow agglutination - 8How can modular proteins with multiple structural and functional domains be studied?Domains separated using proteases
Studied seperately - 9Describe the threee main features of alpha-helical coiled-coil- left-handed superhelix
- 7 repeat units
- two turns
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- (Biochemistry) Biology Fichas sobre Protein diversity, creado por Charlotte Pedley el 21/12/2017.
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- Charlotte Pedley
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