Skin 1 Questions

Skin 1 Questions

1. List some functions of skin

2. Labels: Epidermis, dermis, panniculus / hypodermis / subcut fat, hair root, hair follicle, sweat gland, root hair plexus, artery vein, adipose tissue, Pacinian corpuscle, sebaceous gland, free nerve ending, meissner's corpuscle, pore, hair shaft, arrector pilae muscles.

3. Label the epidermis, dermis & panniculus adiposus

4. What type of epithelium is there on the skin surface?

   • What are the 5 layers (including the basement membrane) of the epidermis?
     • Basement membrane
       • • Stratum spinosum
           • • • How are the cells in this layer attached to one another?
             • What do the granules in this layer contain?
               • Profillagrin is a precursor of fillagrin but what is fillagrin used for?
           • Spine / bulk of epidermis!
         • How is this layer attached to the lamina lucida of the basement membrane?
   • What adaptations are there in the epidermis of a dogs paw?

5. Suggest a possible reason why sheep are more resistant to bacterial infections of the skin than dogs?

6. What are the 3 routes of entry for a drug via the skin? E.g. flea treatment

   • Fusidic acid
     • What's it used to treat?
     • Why is it able to cross the skin barrier?
   • If a drug is too lipophilic what will happen to it?
     • Can hydrophilic drugs cross the skin barrier?
       • YES / NO

7. Cases

   • What's TEN? What goes in through the skin, what come out?
   • What's golden Retriever ichthyosis?
     • It can't be cured so what can be done to get rid of the scaling a bit?
   • What's parakeratosis?
     • What's it caused by? Example of a metabolic disorder cause?

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