Platelets

Platelets

1. Platelet stimulation

   • Adhesion
   • Activation
   • Aggregation

2. Drugs

   • Aspirin: inhibits COX
     • Indications
       • Reduce fever
       • Pain
       • Anti-inflammatory
       • Anti-platelet
       • Acute MI
       • Acute coronary syndromes
       • Acute thrombotic stroke
       • MI prevention
     • Side effects
       • Peptic ulcers
       • Bleeding
       • Hyperventilation
       • Reye syndrome
       • Tinnitus
   • Ticlopidine, clopidogrel, ticagreolor, prasugrel: block the ADP receptor
   • Abciximab, eptifibatide, tirofiban: inhibits Gp IIb/IIIa

3. Disorder symptoms

   • Bleeding from the mucous membranes
   • Epistaxis
   • Petechiae
   • Purpura

4. Platelet disorders

   • Immune thrombocytopenia purpura (ITP)
     • Treatment
       • Steroids
       • IVIG
       • Splenectomy
   • Thrombotic thrombocytopenic purpura (TTP)
   • Bernard-Souiler syndrome
   • Glanzmann thrombasthenia

5. DIC

   • Sepsis
   • Trauma
   • OB complications
   • Pancreatitis
   • Malignancy
   • Transfusion