Cisplatin

Cisplatin

1. Platinol-AQ & Platinol (Brand Names)

2. Cancers Treated

   • Metastatic Testicular Tumors
     • Metastatic Ovarian Tumors
       • Advanced Bladder Cancer
   • First-Line Treatment of Ovarian Cancer
     • Unlabeled Uses
       • Non-Small-Cell Lung Cancer
         • Brain Cancer
           • Adrenal Cortex Cancer
             • Breast Cancer
               • Cervix Cancer
                 • Uterine Cancer
                   • Endometrium Cancer
                     • Head and Neck Cancer
                       • Esophogeal Cancer
                         • Lung Cancer
                           • Liver Cancer
                             • Osteogenic Sarcomas
                               • Numerous Other Malignancies

3. Drug Classification

   • Platinum Based Antineoplastic

4. Drug Reconstitution & Dilution

   • Comes in a liquid form so no reconstitution is required
     • Combined with Mannitol in either NS or D5 1/2 NS 1/2. D5W alone cannot be used.

5. Physiological Concepts

   • Evidence of Tumors
     • Symptoms will vary depending on the type of cancer

6. Non-Drug Treatments or Lifestyle Modifications

   • Use of essential oils
     • Super Foods
       • Nutrients, Foods & Products that help to build up the immune system
         • Get plenty of rest
           • Exercise
             • Get to and maintain a healthy weight

7. Routes of Administrtion

   • Can be used in all populations. Pediatric patients need close monitoring and testing. IV USE ONLY!!

8. Usual Dose & Rate of Administration

   • Dose & Rate will Vary based on patient. Dosed using BSA. Not to be run as a rapid infusion. Typically run over 2 hours

9. Contraindications & Warnings

   • Hypersensitivity to cisplatin or other platinum-containing compounds.
     • Myelosuppressed Patients
       • Patients with pre-existing impaired renal function
         • Patients with a hearing deficit
           • Pregnancy Risk Category D

10. Antidote for Patient Reaction

    • There is no specific antidote available
      • Discontinue Use
        • Administration of whole blood products

11. Drug Drug Interactions

    • Aminoglycosides (i.e. Gentamicin)
      • Loop Diuretics (i.e furosemide)
        • Anticonvulsant Agents
          • Ohter Antineoplastic agents
            • Live Virus Vaccines
              • Drug Food Interactions
                • None

12. Ongoing Monitoring

    • Side effects should be monitored closely as they can be frequent and become more severe with every dose after the fist.
      • Hearing tests are ordered for high dose therapies
        • Blood Tests such as a CBC will be done to monitor electrolytes and organ functions

13. Interesting Fact: First platinum-containing anti-cancer drug

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