762845
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 10 years ago
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| Question | Answer |
| Untreated HIV- Initial Viral Load | Starts low, spikes rapidly, and then falls off again due to immune response |
| Untreated HIV- Initial CD4 Cout | High |
| Untreated HIV- Seroconversion | Non-specific symptoms during initial HIV infection- rash/fever/malaise, patient is most infectious during this time |
| Untreated HIV- 'Latent' Viral Load | Viral count remains steady for a long period (usually at least 2 years) |
| Untreated HIV- 'Latent' CD4 Count | Falls slowly as virus uses them to keep population steady |
| Untreated HIV- Viral Reactivation Viral Load | Viral load begins to increase slowy |
| Untreated HIV- Viral Reactivation CD4 Count | Steadies out as viral load increases, then falls again |
| Untreated HIV- Appearance of AIDs Defining Illness Viral Load | When CD4 falls below 200, virus can replicate freely |
| Drugs- AIDs Defining Illness | Illness only acquired by the severely immunocompromised, so those with them most are most likely HIV+ |
| Untreated HIV- Appearance of AIDs Defining Illness CD4 Count | Falls below 200, then continues to decline till person dies from secondary infections |
| Untreated HIV- Transmission to Child | Can occur at any point during disease progression |
| Untreated HIV- Location of Pathenogensis | Replicates in lympoid organs (spleen, lymph nodes, guts) but mostly in CD4 T cells |
| Untreated HIV- Co-Infection | Immune system is depeleted, opportunistic infections can become deadly i.e. flu |
| Drugs- Nucleotide Reverse Transcriptase Inhibitors | Target reverse transcriptase, by binding to RNA binding pocket |
| Drugs- Non-Nucleotide Reverse Transcriptase Inhibitors | Bind outside RNA binding pocket on Reverse Transcriptase |
| Drugs- Protease Inhibitors | Prevent maturation of virion outside the cell |
| Drugs- Fusion/Entry Inhibitors | Guess what they do |
| Drugs- Integrase Inhibitors | Again, duh |
| HIV Test (Low Risk Patients) | Anti-HIV Igs, but these may take some time to appear in blood after infection |
| HIV Test (High Risk Patients) | Viral RNA, so treatment can begin ASAP |
| AIDs Defining Illness (Examples) | Toxoplasmosis, PCP, CNS lymphoma (the latter only when CD4 is below 50) |
| HAART | Highly Active Anti-Retroviral Therapy |
| Role of HAART | A combination of drugs that target and suppress viral replication, preventing further immune damage |
| Problems with HAART | All drugs have severe side effects, some are severely toxic |
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