Sleeping Sickness (Tissue Protazoa)

Question	Answer
Causative agents	African Tropanomyosis bruceii, subspecies rhodesiense or subspecies gambiense
T.b suspecies rhodesiense- Location	East Africa
T.b suspecies rhodesiense- Anival Vector	None
T.b suspecies gambiense- Location	West Africa
T.b suspecies gambiense- Animal Vector	Tsetse resevoir
Forms	Trypomastigote and Epimastigote
Antigenic Variation	Variation of extracellular antigens allows immune evasion
Life Cycle- Tsetse Bite 1	Tsetse fly injects Metacyclic trypomastigote
Life Cycle- In The Blood	In the blood, converts to bloodstream trypomastigote form
Life Cycle- Multiplication	In various bodily fluids, the trypomastigote multiplies
Life Cycle- Tsetse Bite 2	Blood is consumed, blood trypomastigotes convert to procyclic trypomastigotes in midgut
Life Cycle- Moving from the Midgut	Move into salivary glands and convert to epimastigote form
Life Cycle- Epimastigote Conversion	Epimastigote multiplies, with its offspring converting back to metacyclic trypamastigotes

Resource summary

	Created by gina_evans0312 about 10 years ago