Mind map
Protein Kinase C
Map content
Protein Kinase C
Regulated by two mechanisms
- PHOSPHORYLATION
- Regulates the active site and subcellular localization of the enzyme.
- SECOND MESSENGERS
- Promote protein kinase C's membrane association and resulting pseudosubstrate exposure.
- PHOSPHORYLATION
transduces the myriad of signals promoting lipid hydrolysis.
Structure
- Comprised of an N-terminal regulatory region and a C-terminal catalytic region
- 11 protein kinase C isozymes have been identified and classified into three groups based on their structure and cofactor regulation
- 11 protein kinase C isozymes have been identified and classified into three groups based on their structure and cofactor regulation
- Comprised of an N-terminal regulatory region and a C-terminal catalytic region
Function
- Enzymology
- Protein kinase C typically phosphorylates serine or threonine residues in basic sequences.
- In addition to catalyzing phosphorylation reactions, protein kinase C has ATPase and phosphatase activity.
- Protein kinase C typically phosphorylates serine or threonine residues in basic sequences.
- Enzymology
Biological Function
- in receptor desensitization, in modulating membrane structure events, in regulating transcription.
- in mediating immune responses, in regulating cell growth, and in learning and memory.
Pseudosubstrate Regulation
- Diacylglycerol and Phorbol Esters
- Phosphatidylserine
- Calcium Ions
- Substrates
- Calcium Ions
- Phosphatidylserine
- Diacylglycerol and Phorbol Esters