Glomerular filtration, tubularReabsorption and tubular Secretion

Zulhilmi Zainal
Mind Map by Zulhilmi Zainal, updated more than 1 year ago
Zulhilmi Zainal
Created by Zulhilmi Zainal almost 6 years ago
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Mind Map on Glomerular filtration, tubularReabsorption and tubular Secretion, created by Zulhilmi Zainal on 03/13/2014.
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Glomerular filtration, tubularReabsorption and tubular Secretion
1 Glomerular Filtration
1.1 180L/day
1.1.1 125ml/min
1.2 GFR = Kf x Net filtration pressure (NFP)
1.2.1 (NFP) = (PGC – PBS) – (OnGC - OnBS)
1.2.2 Kf (filtration coefficient) depends on • the hydraulic conductivity (permeability) of the capillary and • the effective surface area available for filtration.
1.3 GFR is directly related to blood pressure
1.4 sympathetic stim DECREASE GFR
1.5 not a selective process
2 Tubular Reabsorption
2.1 All except potassium
2.2 Na+-K- pump and carrier proteins (e.g. glucose transporter or GLUT) always reside on the basolateral membrane.
2.3 Na+ channels and co-transporter proteins (e.g. Na+-glucose symporter, Na+- amino acid symporter, Na+-Cl- symporter, and Na+-H+ antiporter) are on the apical membrane.
2.4 diffusion
2.4.1 Na+, K+, Cl-, urea in the PCT
3 Morphology of epithelial cells lining various sections of the nephron
4 Reabsorption in the Loop of Henle
4.1 descending
4.1.1 water ONLY
4.2 ascending
4.2.1 Electrolytes
5 Reabsorption in the early Distal Convoluted Tubule (DCT)
5.1 Ca2+
5.1.1 passive transport
6 Reabsorption and Secretion in the Collecting Duct
6.1 Principal cells reabsorb Na+ and secrete K+
6.1.1 target for aldosterone and ADH
6.2 intercalated cells reabsorb K+ and HCO3-, and secrete H+
7 tubular secretion
7.1 PCT
7.1.1 H+: variable (via Na+-H+ antiporters)
7.1.2 NH4+: variable, increase in acidosis (antiporters)
7.1.3 Urea: variable (diffusion)
7.1.4 Creatinine: small amount
7.2 thin LoH
7.2.1 Urea: variable (recycling from collecting duct)
7.2.2 NH4+: variable (recycling from thick ascending loop of Henle)
7.3 CD
7.3.1 K+: variable amount to adjust to dietary intake (via leakage channels of the principle cells)
7.3.2 H+: variable amount to maintain acid-base homeostasis (via proton pump)
8 Sites of action of diuretics
9 Summary of basic renal processes
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