1. Antibodies are made by lymphocytes,
one of the two main types of leukocyte.
2. A lymphocyte can only make one type of antibody so a huge
number of different lymphocyte types are needed. Each
lymphocyte puts some of the antibody that it can make into its
plasma membrane with the antigen-combining site projecting
outwards.
3. When a pathogen enters the body, its
antigen binds to the antibodies in the plasma
membrane of one type of lymphocyte.
4. When the antigen binds to the antibodies
on the surface of a lymphocyte, this
lymphocyte becomes active and divides by
mitosis to produce a clone of many identical
cells.
5. The clone of cells starts to produce large
quantities of the same antibody - the antibody
needed to defend the body against the pathogen.
AIDS - a syndrome caused by a vius
AIDS shows how vital the bodies defenses against disease are.
Destruction of the immune system
lead inevitably to death.
AIDS is an example of a syndrome.
A syndrome is a group of symptoms that are found
together. Individuals with AIDS have low numbers of
one type of lymphocyte together with weight loss
and a variety of diseases cause by viruses,
bacteria, fungi and protozoa. These diseases
weaken the body and eventually cause death.
Cause:
HIV causes AIDS
The virus infects a type of lymphocyte that
plays a vital role in antibody production.
Over a period of years these lymphocytes are
destroyed and antibodies cannot be produced.
Without a functioning immune system, the
body is vulnerable to pathogens that would
normally be controlled easily.
Transmission
HIV does not survive for long outside
of the body and cannot easily pass
through the skin.
Transmission involves the transfer
of bodily fluids from on an infected
person to an uninfected one.
Through small cuts or tears in the
vagina, penis, mouth or intestine
during vaginal, anal or oral sex.
In traces of blood on a hypodermic needle
that is shared by intravenous drug abusers.
Across the placenta from mother to
baby, or through cuts during childbirth or
in milk during breast-feeding.
In transfused blood or with blood products such as
Factor VIII used to treat hemophiliacs.
Social Implications
Family and friends suffer grief.
Families become poorer if the individual
with AIDS was the wage earner and is
refused life insurance.
Individuals infected with HIV may become
stigmatized and not find partners, housing or
employment.
Sexual activity in a population may be
reduced because of the fear of AIDS.