Clinical Pathology

Clinical Pathology

1. Other Tests (Less routine)

   • Electromyography/biopsies

2. Muscle Leakage Enzymes

   • Creatine Kinase (CK)
     • High concentration in myocyte/brain cytoplasm
       • Skeletal and Cardiac
     • Functions by making ATP available for contraction
       • Phosphorylates ADP from phosphocreatinine
     • Multiple isoenzymes in specific locations
       • CK-1
         • Brain
       • CK-2
         • Cardiac muscle > Skeletal
       • CK-3
         • Skeletal muscle > Cardiac
       • CK-4
         • Mitochondrial membranes
       • We don't quantitate the different enzymes
     • Very Short Half Life
       • ~6.5 hours max
       • High CK maintained with Persistent or Ongoing muscle injury
   • Aspartate Aminotransferase (AST)
     • See also: Liver
     • Longer Half Life
       • Increases more gradually after injury
         • Persists for longer than CKF
   • Lactate Dehydrogenase (LDH)
   • Cardiac Troponin 1