Alpha 1 Adrenergic Receptor Pathway

Descrição

Year 2 Quiz sobre Alpha 1 Adrenergic Receptor Pathway, criado por gina_evans0312 em 03-11-2013.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 mais de 10 anos atrás
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Resumo de Recurso

Questão 1

Questão
Which Gprotein causes the activation Phospholipase CBeta?
Responda
  • Gq
  • Gs
  • Gi

Questão 2

Questão
How is Phospholipase CBeta activated?
Responda
  • By GTP binding to the alpha subunit of the Gq protein
  • By ATP binding to the alpha subunit of the Gq protein
  • By GMP binding to the alpha subunit of the Gq protein

Questão 3

Questão
What is broken down by phospholipase CBeta?
Responda
  • Phosphatidynositol 4,5 bisphophate
  • Phosphatidynositol 3,5 bisphophate
  • Phosphatidynositol 2,4 bisphophate

Questão 4

Questão
Which product of the PCbeta pathway causes the release of calcium from the ER?
Responda
  • IP3
  • Diacylglycerol

Questão 5

Questão
What role(s) does the released Ca perform?
Responda
  • Activates protein kinase C
  • Activates protein kinase B
  • Activates various Ca dependent protein kinases

Questão 6

Questão
What residues are phosphorylated by the protein kinases activated by this pathway?
Responda
  • Serine
  • Threonine
  • Tyrosine

Questão 7

Questão
Which subunit of Protein Kinase C contains the pseudosubstrate domain?
Responda
  • PS
  • C1A
  • C4

Questão 8

Questão
What is the function of subunut C1A
Responda
  • DAG binding site
  • Calcium binding site
  • Phosphatidyl serine binding site

Questão 9

Questão
Do Ca 2+ and phosphatidyl serine bind to subunit C2?
Responda
  • Yes
  • No

Questão 10

Questão
Which subunits are part of the catalytic domain?
Responda
  • C1A
  • C3
  • C4
  • PS
  • C5

Questão 11

Questão
ATP binds to C2, True or False?
Responda
  • True
  • False

Questão 12

Questão
When IP3 causes the increase in cytosolic calcium, what happens to protein kinase C?
Responda
  • It moves to the membrane and binds with DAG
  • It remains in the cytoplasm and binds with DAG

Questão 13

Questão
Once protein kinase C has bound to DAG in the membrane, what does it then bind to to release the pseudosubstrate from its active site?
Responda
  • Phosphatidylserine
  • Phosphatidylglycine
  • Phosphatidylglutamate

Questão 14

Questão
Which of the following is a tumor promoting agent?
Responda
  • Phorbol ester
  • Orphol ester
  • Phenyl ester

Questão 15

Questão
How do tumor promoting agents effect Phospholipase CBeta?
Responda
  • They bind without being degraded, so it becomes hyperactive
  • They stop the alpha subunit binding, so it becomes unreactive
  • They cause the multiplication of the number of PCbeta enzymes in the cell, causing hyperactivity

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