Zusammenfassung der Ressource
Interstitial Lung Disease
(reduced compliance, diffusion
capacity and lung volume)
- Fibrosing
- UIP: Usual: unknown cause,
temporally heterogeneous,
honeycomb lung, expanded
alveolar septa
- NSIP:
Non-specific:
idiopathic,
temporally
homogeneous
- COP: Cryptogenic organising pneumonia
- Autoimmune related: RA, SLE
- Pneumoconiosis: inhaled dusts:
anthracosis, silicosis, asbetosis
- Asbestosis: thick
collagen layer on lung
parenchyma, may calcify
- Acute interstitial lung disease
- ARDS: Acute Respiratory Distress Syndrome
/ DAD: Diffuse alveolar damage
- MACRO: red heavy lungs
- MICRO:
- Oedema in alveolar walls
- Hyaline membranes:
fibrin + epithelial cell
debris
- Type II pneumocytes
proliferate &
differentiate to type I
- Causes
- Trauma,
infection,
shock, gastric
aspiration, gas
inhalation, DIC
- Respiratory distress in the newborn
= ARDS in newborn
- Birthweight <2.5kg,
<36wks gestation,
maternal diabetes,
caesarean
- Insufficient surfactant
- Alveoli collapse, hypoxia
- Cell damage, oedema, fibrin
- Hyaline membrane
- Acute interstitial pneumonia
= ARDS without known
cause
- Sarcoidosis
- Systemic
disease,
disseminated
well-formed
granulomas