Liver Pathology

Budd-Chiari syndrome
1. Obstruction of IVC
2. Obstruction of hepatic veins
3. Absence of JVD
4. Congestion of liver
Reye's syndrome
1. Children
2. Aspirin
3. Viral infection
4. Hepatoencephalopathy
Wilson disease: copper accumulation
1. Organs
  1. Liver
  2. Brain
  3. Cornea
  4. Kidneys
  5. Joints
2. Symptoms
  1. Cirrhosis
  2. Corneal deposits called Kayser-Fleischer ring
  3. Hepatocellular carcinoma
  4. Hemolytic anemia
  5. Basal ganglia degeneration
  6. Parkinsonian symptoms
  7. Hepatoencephalopathy
  8. Dementia
  9. Fanconi's syndrome: proximal tubule dysfunction
3. Treatment: penicillamine
Hemochromatosis (bronze diabetes)
1. Cirrhosis
2. Diabetes mellitus
3. Skin pigmentation
4. Primary: AR disorder
5. Secondary: transfusions (chronic)
6. Treatment
  1. Phlebotomy
  2. Deferoxamine
Alpha 1-antitrypsin deficiency
1. Early onset emphysema (panacinar)
2. Cirrhosis
  1. Jaundice
  2. Elevated LFTs
Hepatocellular carcinoma
1. Increased risk
  1. Hepatitis B, C
  2. Wilson disease
  3. Hemochromatosis
  4. Alpha 1-antitrypsin deficiency
  5. Alcoholic cirrhosis
  6. Carcinogen exposure
2. Serum marker: alpha-fetoprotein

Zusammenfassung der Ressource

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