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Liver Pathology

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Liver Pathology

Budd-Chiari syndrome
- Obstruction of IVC
- Obstruction of hepatic veins
- Absence of JVD
- Congestion of liver
Reye's syndrome
- Children
- Aspirin
- Viral infection
- Hepatoencephalopathy
Wilson disease: copper accumulation
- Organs
  - Liver
  - Brain
  - Cornea
  - Kidneys
  - Joints
- Symptoms
  - Cirrhosis
  - Corneal deposits called Kayser-Fleischer ring
  - Hepatocellular carcinoma
  - Hemolytic anemia
  - Basal ganglia degeneration
  - Parkinsonian symptoms
  - Hepatoencephalopathy
  - Dementia
  - Fanconi's syndrome: proximal tubule dysfunction
- Treatment: penicillamine
Hemochromatosis (bronze diabetes)
- Cirrhosis
- Diabetes mellitus
- Skin pigmentation
- Primary: AR disorder
- Secondary: transfusions (chronic)
- Treatment
  - Phlebotomy
  - Deferoxamine
Alpha 1-antitrypsin deficiency
- Early onset emphysema (panacinar)
- Cirrhosis
  - Jaundice
  - Elevated LFTs
Hepatocellular carcinoma
- Increased risk
  - Hepatitis B, C
  - Wilson disease
  - Hemochromatosis
  - Alpha 1-antitrypsin deficiency
  - Alcoholic cirrhosis
  - Carcinogen exposure
- Serum marker: alpha-fetoprotein