Inflammatory Process

Inflammatory Process

1. 1- infection gets into the dermis of the skin. This is the initiating cause

2. 2 - Release of inflammatory mediators

   • The damaged cells from the invasion of the bacteria release inflammatory mediators. These include Histamine, Prostaglandins, Leukotrienes and Cytokines.
     • These cause Vasodilation which creates the redness around the infected area, increase vascular permeability and creates the pain the person would feel.
       • The Cytokines released cause the fever like symptoms that can be felt and malaise.
         • Bradykinins and Prostaglandins cause pain.

3. 3- The vascular response

   • Vasodilation occurs increasing blood supply.
     • This causes erythema and the warmth felt.
   • Exudate is squeezed out of the blood vessels and accumulates in the tissues.
     • This causes the swelling
   • Exudate dilutes toxins and plasma proteins help limit infection.
   • Complement is activated and directly destroys bacteria.
   • Exudate carries bacteria, cell debris and immune cells to lymph vessels

4. 4- The cellular response

   • Macrophages have the ability to ingest microorganisms (phagocytosis)
     • Causes the macrophage to release Cytokines that cause fever.