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Quiz

MO3 Drug lead discovery

Mer Scott 6 Fragen

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Fragen in diesem Quiz (6)

  1. 1A drug lead is something [blank_start]likely[blank_end] to be therapeutically useful. It is used as a starting point for [blank_start]chemical modifications[blank_end] to improve potency, selectivity, or pharmacokinetic parameters.
    1. Alikely
    2. Bcertain
    3. Cchemical modifications
    4. Dphysical alterations
  2. 2The higher the potency the better.
    1. ARichtig
    2. BFalsch
  3. 3The three broad methods to finding a lead are random screening, synthesis, and direct screening.
    [blank_start]Random[blank_end] screening includes screening of synthetic compounds from in house libraries, combinatorial chemistry/parallel synthesis, screening of fragment libraries, and screening of known drugs or natural product libraries. Combinatorial chemistry [blank_start]rapidly[blank_end] generates a large number of structurally related molecules.
    [blank_start]Synthesis[blank_end] is also known as "Targeted Drug Discovery" or Rational Design. The Topliss scheme can be followed to find the most appropriate aliphatic [blank_start]substituents[blank_end].
    [blank_start]Direct[blank_end] Screening includes endogenous compounds, structure based drug design, virtual screening, and de novo (new) design.
    1. ARandom
    2. BDirect
    3. CSynthesis
    4. Drapidly
    5. Esubstituents
  4. 4What is a pharmacophore?
    1. AThe 3D spatial arrangement of groups responsible for a defined biological activity.
    2. BAn atom or group whose presence is responsible for the vibrational frequency of a compound.
    3. CA structurally similar isomer.
  5. 5Many new drugs are created by enhancing the side effects of existing drugs.
    1. ARichtig
    2. BFalsch
  6. 6Drug metabolism studies are usually not worthwhile when developing drugs or removing side effects.
    1. ARichtig
    2. BFalsch

Informationen

Beschreibung
PHCY211 (Molecules) Quiz am MO3 Drug lead discovery, erstellt von Mer Scott am 07/04/2018.
Sprache
English
Aufrufe
13
Schlagwörter
phcy211molecules
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