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Quiz

MO23 Receptors as Drug Targets

Mer Scott 8 Fragen

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  1. 1Choose the incorrect statement about ionotropic receptors.
    1. ATheir structure is multiple membrane-spanning subunits surrounding a pore
    2. BThey involve direct coupling
    3. CNicotinic acetylcholine (Ach) receptor (nAChR) and gamma-aminobutyric acid type A (GABAA) receptors are examples
    4. DSignal leads to action of an enzyme or ion channel via second messengers
  2. 2G-protein coupled receptors are found in the [blank_start]membrane[blank_end], coupled to [blank_start]intracellular[blank_end] effector systems via G-proteins. They have 7 membrane spanning [blank_start]helices[blank_end]. As the largest family of receptors, at least [blank_start]30%[blank_end] of drug targets are GPCRs. Ligand binding induces a signal via a [blank_start]conformational change[blank_end], and this leads to action of an enzyme or ion channel via [blank_start]second messengers[blank_end].
    1. Amembrane
    2. Bintracellular
    3. Chelices
    4. D30%
    5. Econformational change
    6. Fsecondary messengers
  3. 3Which two enzymes do GPCRs commonly activate?
    1. AAdenylate cyclase
    2. BPhosphate kinase
    3. CPhospholipase C
    4. DAcetylate cyclase
  4. 4Kinase linked receptors have an [blank_start]extracellular[blank_end] ligand-binding domain linked by a [blank_start]transmembrane helix[blank_end] to an [blank_start]intracellular[blank_end] kinase domain. They [blank_start]enzymatically[blank_end] transfer [blank_start]phosphate[blank_end] groups to a substrate and are activated by a wide variety of protein mediators like growth factors, cytokines and hormones. They work via [blank_start]direct coupling[blank_end].
    1. Aextracellular
    2. Btransmembrane helix
    3. Cintracellular
    4. Denzymatically
    5. Ephosphate
    6. Fdirect coupling
    7. Gindirect coupling
  5. 5Order the steps of how kinase linked receptors work:

    [blank_start]3[blank_end]. ATP leads to autophosphorylation of Tyrosine
    [blank_start]4[blank_end]. Intracellular (relay) proteins bind to the phoshpotyrosines allowing control of cell functions
    [blank_start]1[blank_end]. Ligand binds to extracellular domain
    [blank_start]2[blank_end]. Dimerisation occurs
    1. A3
    2. B2
    3. C1
    4. D4
    5. E4
    6. F3
    7. G2
    8. H1
    9. I1
    10. J2
    11. K3
    12. L4
    13. M2
    14. N3
    15. O4
    16. P5
  6. 6Choose the correct statement about nuclear receptors.
    1. AThey are in the membrane
    2. BThey regulate gene translation
    3. CLigand-receptor interaction induces trimerization
    4. DCan translocate from cytoplasm to nucleus
  7. 7Nuclear receptors are responsible for the effects of [blank_start]10-15%[blank_end] of all drugs. Many regulate the expression of [blank_start]drug metabolising enzymes[blank_end] (e.g. CYPs) & transporters. Many [blank_start]illnesses[blank_end] are associated with malfunctioning of the nuclear receptor system: Inflammation, cancer, diabetes, [blank_start]cardiovascular[blank_end]
    disease, obesity, and [blank_start]reproductive[blank_end] disorders.
    1. A10-15%
    2. B30%
    3. Cdrug metabolising enzymes
    4. Dillnesses
    5. Ecardiovascular
    6. Freproductive
  8. 8Order the nuclear receptor mode of action:
    [blank_start]3[blank_end]. Liganded receptors dimerise and translocate to the nucleus
    [blank_start]1[blank_end]. Ligand diffuses into cell
    [blank_start]2[blank_end]. Ligand binds to NR
    [blank_start]5[blank_end]. Recruit other proteins forming a complex to promote transcription of multiple genes
    [blank_start]4[blank_end]. Activate (or repress) genes by binding to Response Elements
    1. A3
    2. B1
    3. C2
    4. D5
    5. E4

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Beschreibung
PHCY211 (Molecules) Quiz am MO23 Receptors as Drug Targets, erstellt von Mer Scott am 14/04/2018.
Sprache
English
Aufrufe
10
Schlagwörter
phcy211molecules
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