Karteikarten
BMS04-1039-Lec - Control of gene expression 2 (Epigenetics, Chromatin, small RNAs)
Karten in diesem Stapel (16)
- 1Do epigenitical changes involve changes in DNA?No, it is changes in gene activity/expression
- 2What are two mechanisms of epigenetical modification?Histone modification
DNA methylation - 3What are chromatins made of?Nucleosomes in a string
- 4What is the structure of a nucleosome?Segment of DNA wrapped around 8 histone proteins
- 5What are histones?Proteins w/ globular head and a charged N terminal tail
- 6What are the primary targets of histone modificaton? How do they impact the chromatin?Histone tails
They change condensation reactions, affecting DNA/protein binding - 7Acetylation can turn genesOn and Off
- 8Methylation can turn geneson and off
- 9Phosphorylation can turn genesOn
- 10When does DNA methylation happen ? What about de novo?After DNA replication finishes between parental-->daughter strand
In stem cells/cancer cells - 11What is the only base able to be methylated?Cytosine
Protrudes from 5 position, making DNA more compact/OFF - 12What are Cp6 Islands? Where are they usually?regions rich in cytosine-guanine
they are usually upstream of coding regions
50-60% C-6s are methylated - 13What does the epigenetic code consist of?DNA sequence+ DNA methylation+histone modification
- 14Are epigenetical changes reversible?Yes, can reverse abnormal and add beneficial modifications
- 15What does SAHA (form of epigenetic therapy) do?Inhibit histone deacetylase (prevent deacetylation) to increase T cell activity
- 16How does 5-azacytidine treat myelodysplastic syndrome?Inhibits DNA methyltransferase, so no methylation
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- Beschreibung
- BMS04 - Genes and gene expression Karteikarten am BMS04-1039-Lec - Control of gene expression 2 (Epigenetics, Chromatin, small RNAs), erstellt von Evian Chai am 16/04/2020.
- Erstellt von
- Evian Chai
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