Flashcards
BMS03-1022- A pharmacological perspective of the autonomic nervous system
Cards in this deck (28)
- 1What are the two subdivisions of the autonomic nervous system, and what are their functions?1. Sympathetic
2. Parasympathetic
Aid in maintaining homeostasis - 2What is the general order of events in nerve transmission in the Autonomic Nervous System?1. Signal sent from PNS to preganglionic neuron
2. Preganglionic neuron synapses at ganglion with postganglionic neuron
3. Postganglionic neuron synpases with neuromuscular junction at effector tissue - 3The preganglionic neuron for the Sym. NS is ... and is ... transmission The postganglionic neuron for the Sym. NS is ... and is ... transmissionShort, cholinergic
Long, adrenergic - 4The nerves of the SNS arise from where?Thoracic/lumbar
- 5The preganglionic neuron for the Parasym.NS is ... and is ... transmission The postganglionic neuron for the Parasym. NS is ... and is ... transmissionlong, cholinergic
Short, cholinergic - 6Nerves of the Parasym. NS arise from?cranial/sacral
- 7What is the role of NANC transmission?Fine tune signalling
- 8Is the muscarinic receptor cholinergic or adrenergic? What neurotransmitter does it receive, and how? Which division of the ANS is it for?Cholinergic
ACh, it is G protein coupled
PNS - 9Which muscarinic receptors act on cardiac muscle and lower cAMP, lowering heart rate as a result?M2
- 10Which muscarinic receptors act on smooth muscle receptors and increase IP3/DAG, increasing contraction as a result?M3 (eg. bronchoconstriction)
- 11Is the nicotinic receptor cholinergic or adrenergic? What neurotransmitter does it receive, and how? Which division of the ANS is it for?Cholinergic
ACh, through muscle/ganglionic receptors that have cation channels, causing depolarisation
PNS - 12Which adrenergic receptor is coupled with Gq, and increases IP3/DAG/Ca2+ to increase contraction?A1
- 13Which adrenergic receptor is coupled with Gi, and blocks adenylyl cyclase to lower noradrenaline activity?A2
- 14What neurotransmitter is used by adrenergic (SNS) receptors?Noradrenaline/adrenaline
- 15What adrenergic receptor is coupled with Gs and increases cAMP to increase noradrenaline activity?3 subtypes of Beta receptor
- 16What is the main functional difference between alpha and beta adrenergic receptors?Alpha receptors are mainly responsible for stimulating effector cells/vasoconstriction
Beta receptors are mainly responsible for relaxing effector cells/vasodilaton - 17Where is the ENS, what form of transmission does it do, and what are some functions?In the GI tract
NANC transmission
Peristalsis, secretion, fluid transport etc. - 18What treats MI, Hypertension, and heart failure?B1 Receptor antagonists
- 19What treats asthma through bronchodilation?B2 Receptor agonist
OR
Muscarinic receptor antagonist - 20How does botox reduce muscle spasm/wrinkles?It blocks the release of ACh
- 21The SNS causes vasoconstriction in the ... and vasodilation in....Viscera (internal organs)
skeletal muscle - 22Does the PNS or SNS cause bronchoconstriction?PNS
- 23Does the PNS or SNS cause pupil dilation?SNS
- 24The ... relaxes the urethra while the ... relaxes the bladderPNS
SNS - 25Is body temperature regulated by both SNS/PNS?No, only the SNS
- 26Does the SNS impact gastrointestinal secretions?No, only the PNS increases it (SNS doesnt change it)
- 27AYes, except for adrenaline in the SNS
- 28What usually dominates control of HR?PNS
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- Description
- Recall the two divisions of the autonomic nervous system (ANS) Outline the anatomical differences between the sympathetic and parasympathetic motor (efferent) nerves of the ANS Recall the neurotransmitters and receptors present at the chemical synapses in the ganglia and neuro-effector junctions of the ANS Describe the effects of the sympathetic and parasympathetic nervous system on major organ systems Describe the main mechanism by which drugs can alter synaptic transmission clinical drugs
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- Evian Chai
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