BMS03-1022- A pharmacological perspective of the autonomic nervous system

Description

Recall the two divisions of the autonomic nervous system (ANS) Outline the anatomical differences between the sympathetic and parasympathetic motor (efferent) nerves of the ANS Recall the neurotransmitters and receptors present at the chemical synapses in the ganglia and neuro-effector junctions of the ANS Describe the effects of the sympathetic and parasympathetic nervous system on major organ systems Describe the main mechanism by which drugs can alter synaptic transmission clinical drugs
Evian Chai
Flashcards by Evian Chai, updated more than 1 year ago
Evian Chai
Created by Evian Chai about 4 years ago
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Resource summary

Question Answer
What are the two subdivisions of the autonomic nervous system, and what are their functions? 1. Sympathetic 2. Parasympathetic Aid in maintaining homeostasis
What is the general order of events in nerve transmission in the Autonomic Nervous System? 1. Signal sent from PNS to preganglionic neuron 2. Preganglionic neuron synapses at ganglion with postganglionic neuron 3. Postganglionic neuron synpases with neuromuscular junction at effector tissue
The preganglionic neuron for the Sym. NS is ... and is ... transmission The postganglionic neuron for the Sym. NS is ... and is ... transmission Short, cholinergic Long, adrenergic
The nerves of the SNS arise from where? Thoracic/lumbar
The preganglionic neuron for the Parasym.NS is ... and is ... transmission The postganglionic neuron for the Parasym. NS is ... and is ... transmission long, cholinergic Short, cholinergic
Nerves of the Parasym. NS arise from? cranial/sacral
What is the role of NANC transmission? Fine tune signalling
Is the muscarinic receptor cholinergic or adrenergic? What neurotransmitter does it receive, and how? Which division of the ANS is it for? Cholinergic ACh, it is G protein coupled PNS
Which muscarinic receptors act on cardiac muscle and lower cAMP, lowering heart rate as a result? M2
Which muscarinic receptors act on smooth muscle receptors and increase IP3/DAG, increasing contraction as a result? M3 (eg. bronchoconstriction)
Is the nicotinic receptor cholinergic or adrenergic? What neurotransmitter does it receive, and how? Which division of the ANS is it for? Cholinergic ACh, through muscle/ganglionic receptors that have cation channels, causing depolarisation PNS
Which adrenergic receptor is coupled with Gq, and increases IP3/DAG/Ca2+ to increase contraction? A1
Which adrenergic receptor is coupled with Gi, and blocks adenylyl cyclase to lower noradrenaline activity? A2
What neurotransmitter is used by adrenergic (SNS) receptors? Noradrenaline/adrenaline
What adrenergic receptor is coupled with Gs and increases cAMP to increase noradrenaline activity? 3 subtypes of Beta receptor
What is the main functional difference between alpha and beta adrenergic receptors? Alpha receptors are mainly responsible for stimulating effector cells/vasoconstriction Beta receptors are mainly responsible for relaxing effector cells/vasodilaton
Where is the ENS, what form of transmission does it do, and what are some functions? In the GI tract NANC transmission Peristalsis, secretion, fluid transport etc.
What treats MI, Hypertension, and heart failure? B1 Receptor antagonists
What treats asthma through bronchodilation? B2 Receptor agonist OR Muscarinic receptor antagonist
How does botox reduce muscle spasm/wrinkles? It blocks the release of ACh
The SNS causes vasoconstriction in the ... and vasodilation in.... Viscera (internal organs) skeletal muscle
Does the PNS or SNS cause bronchoconstriction? PNS
Does the PNS or SNS cause pupil dilation? SNS
The ... relaxes the urethra while the ... relaxes the bladder PNS SNS
Is body temperature regulated by both SNS/PNS? No, only the SNS
Does the SNS impact gastrointestinal secretions? No, only the PNS increases it (SNS doesnt change it)
A Yes, except for adrenaline in the SNS
What usually dominates control of HR? PNS
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