Flashcards
Controlling T-Cell Activation
Cards in this deck (7)
- 1Costimulation- RoleSecondary signal required to prevent overstimulation of T-cells
- 2Costimulation- SignalBinding of CD28 (on T-cells) and B7.1/7.2 on APC
- 3Costimulation- Anergy SignalIf antigen is presenting with Co-stimulation occurring, T-cell is permanently deactivated
- 4Costimulation- Prevention of AutoimmunityNon Professional APCs don't have B7, so T-cells cannot be activated by normal, native cells
- 5Inhibition of T-cells- CTLA-4A CD28 homologue activated by CD28-B7 binding that competes with CD28 for B7
- 6Inhibition of T-cells- CTLA-4 Affinity20x higher than B7
- 7Inhibition of T-cells- CTLA-4 RoleSignals T cell to downregulate response
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- Year 2 Flashcards on Controlling T-Cell Activation, created by gina_evans0312 on 13/03/2014.
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- gina_evans0312
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