Barriers

Barriers

1. PHYSIOLOGICAL

   • ph, temp, body sec
   • fever response
   • acidity of stomach
   • WBCs
   • lysozymes

2. ANATOMICAL

   • Skin, mucous membrane
   • mucuos entraps,ciliary movement of epi cells expels out

3. PHAGOCYTIC

   • Impo mech of innate immu
   • performed my leucocytes
   • infection,total count of leucocytes increases
   • circulating phagocytes in humans
   • phago- macrophages & nuetrophils
   • macro-irregular, large, engulf microbes, bacterial cells & cellular debris
   • site of infect, monocytes, convert to macrophages
   • macro-bacterial enzymes & free radicals, destroy pathogens.

4. INFLAMMATORY

   • inflammatory response
   • leakage of vascular fluid, serum proteins, antibact props
   • influx of phagocytic cells
   • chem alarm signals-histamine, serotonin, plastoglandin
   • respones inhibit & destroy invading bact