Bacterial Injury - created from Mind Map

Page 1

Intracellular

Extracellular

Host Immune response

Ecoli and Shegilla with GI Epethilial

TB in Microphages

Rickettsia in Endothelial Cells

Chlamydia

Stop Protein Synthesis

Cause cell to replicate and lyse

Block fusion of Phagosome and Lysosome

Cause Rashes = Vasculitis

Hepatitis, Pneumonia and Q fever

CNS Damag and Death: Rocky mountain Fever

Female Sterility

Blindness

Secreted Proteins Exotoxins

Bacterial Housekeeping Enzymes

Exotoxin that do not benefit bacteria

Regulatory functions

Neurotoxic

S. aureus

C. Perfringens

Proteases cause epidermal cells to lose adhesions and squamous shape to make infection spread occurs easily

Cause gas gangrene while consuming host's cell thru alpha toxin Lechtiniase

S. pyogenes

Scarlet fever phagoencoded pyrogenic toxin

C. diphtheria

A subunit bind to B binding subunit to stop protein synthesis after accessing to host's cell - kill cell

C. botulism

C. tetnai

A subunit block a protein that has a function in Neurotransmitters release which leads to paralysis = diaphragm and chest muscle to stop functioning which lead to death

Endotoxin

Superantigen

High LPS : high TNF, IL-1 IL-12

Low LPS

Septic shock

DIC

ARDS

Recruiting Leukocytes and activates T-cells

bind to T-cell which cause a storm of cytokines which cause acute toxic syndrome

S. aureus

S. pyogenes