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T cell development and activation

Alyssa Walsh 8 questions

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Questions in this quiz (8)

  1. 1The cells that leave the thymus and travel to the periphery are:
    1. Adouble negative T cells
    2. Bimmature T cells
    3. Csingle positive T cells
    4. Ddouble positive T cells
    5. Eeffector T cells
  2. 2Positive selection in the thymus includes:
    1. AT cells that interact with high avidity to a dendritic cell expressing self MHC are deleted
    2. BT cells that do not bind at all to self MHC molecules and self peptide are selected
    3. CT cells that interact with low avidity to thymic epithelial cells are selected
    4. DNone of the above
  3. 3Generation of diversity in T cells is very similar to that of B cells EXCEPT that T cells do not:
    1. AUndergo somatic hypermutation
    2. BHave multiple genes in the germ line
    3. CUndergo junctional and insertional diversity
    4. DUndergo random combination of chains
    5. ENone of the above
  4. 4All of the following statements about superantigens are true EXCEPT:
    1. ASuperantigens are required to be processed by the APC for presentation to T cells via the MHC
    2. BSuperantigen activation results in the massive production of cytokines by CD4+ T cells
    3. CSuperantigens can be produced by bacteria (Staphlococcal bacteria), viruses (Rabies virus) and mycoplasms
    4. DSuperantigens activate all T cells with a particular V-beta gene segment on the TCR, irrespective of their V-alpha expression.
  5. 5The first signal of T cell activation requires interaction between:
    1. AThe antigen-MHC complex on the APC and the TCR and CD4 or CD8 on the T cell
    2. BThe antigen-MHC complex on T cells and TCR on the APC
    3. CThe antigen-MHC complex on the APC andthe TCR plus co-stimulatory molecules
    4. DThe antigen-MHC complex on the APC and the BCR and CD4
  6. 6Which one of the following statements is FALSE?
    1. AThe first signal for a T cell to become activated is recognition of specific peptide bound to a MHC I or MHC II molecule on an APC by the T cell receptor
    2. BThe second signal for naïve T cell activation is provided by the co-stimulatory molecule CD95
    3. CIf a T cell receives the first signal through the TCR but not the costimulatory second signal, the T cell may become anergic or undergo apoptosis
    4. DThe third signal of T cell activation is provided by cytokines
  7. 7Which one of the following statements is TRUE
    1. AOnce common lymphoid precursors arrive in the thymus and migrate to the outer cortex they differentiate into Pro-T cells which have the phenotype CD4-CD8-TCR+CD3-
    2. BMaturing T cells migrate deeper into the cortex, they start to express CD3 and TCRβ chain and are known as double positive T cells
    3. CNegatives election occurs prior to positive selection in the thymus
    4. DDuring negative selection, T lymphocytes whose TCRs bind strongly to self-peptide/MHC complexes get eliminated
  8. 8Superantigens have been implicated in several diseases. What properties of superantigens distinguish them from conventional antigens?
    1. AThey bind to the outside of the MHC binding groove
    2. BThey do not require MHC processing
    3. CCan artificially bridge the TCR and MHC
    4. DThey bind with the conserved regions of the Vβ domain
    5. EThey induce enormous T cell proliferation (2-20%) as compared to 0.001% for a conventional Ag
    6. FAll of these
    7. GNone of these

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Description
Immunology Quiz on T cell development and activation, created by Alyssa Walsh on 07/10/2021.
Language
English
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6
Tags
immunology
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