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Questions in this quiz (26)
1All of the following are true about Henderson-Hasselbalch equation except
- AIf pKa < pH then A- > HA i.e. dissociated
- Bif pKa > pH, then HA > A- i.e. not dissociated
- CWhen Concentration of A- and HA are equal then pH=pKa
- DNone of the above
2All of the following are sequence of events in the transport of bicarbonate
- ATissues like liver generate CO2 by cellular respiration
- BCO2 + H2O in the presence of carbonic anhydrase in RBC results in H2CO3
- CH2CO3 dissociates into H+ and HCO3-
- DH+ is taken up by the Hemoglobin and HCO3- is exchanged for PO4-
3All of the following regarding Oxy-Hb dissociation curve are true except?
- AShift to the right means more O2 is released to the tissues
- BLow pH, high PCO2, increased H+ concentration and increased 2,3DPG all cause a shift to the right
- CHemoglobin and Myoglobin both have the same type of curve
4Proton binding by Hb reduces oxygen affinity is called the Bohr effect
- ATrue
- BFalse
5Oxygen has >200 times greater affinity for Hb than CO
- ATrue
- BFalse
6all of the following regarding enzymes are true except?
- AThe velocity of all enzyme reactions is dependent on the concentration of the Substrate
- BThe initial velocity of product formation (vi) proportional to Concentration of ES
- CVelocity continues to increase with increasing substrate concentration
7In competitive inhibition Vmax is decreased and Km is unchanged, in noncompetitive inhibition Vmax remains unchanged and Km is changed
- ATrue
- BFalse
8All of the following regarding allosteric enzyme are correct except
- ARegulation via allosterism can be more powerful since activators don't use catalytic site
- BInhibitors have stronger effect than at active site
- Cchanges can be rapid
- DAllosteric enzyme has a sigmoid curve
- ENone of the above
- Fall of the above
9All of the following are irreversible steps in Glycolysis except
- AGlucose to Glucose 6 phosphate
- BFructose 6 phosphate to Fructose 1,6 bisphosphate
- CPEP to Pyruvate
- DGlyceraldehyde 3 phosphate to 1,3 Bisphosphoglycerate
10All of the following regarding Glucokinase are true except?
- Alow Km for glucose
- BHigh Vmax for glucose
- Cindirectly inhibited by fructose 6 phosphate and stimulated by glucose
- DNot inhibited by Glucose 6 phosphate
- EMutation of this enzyme cause MODY 2 and also play a role in gestational diabetes
11All of the following about PFK1 are true except
- APFK 1 irreversibly commits G6P to glycolysis
- BPFK1 is allosterically inhibited by ATP
- CPFK1 is allosterically activated by AMP and fructose 2,6 bisphosphate
- Dnone of the above
12Pyruvate Kinase deficiency causes hemolytic anemia
- ATrue
- BFalse
13All of the following are true about Warburg effect except?
- AProliferating cells get ATP from glycolysis not Oxidative Phosphorylation
- BGlycolysis is up regulated by oncogenes
- CDamaged mitochondria so no TCA cycle only glycolysis
- DWorks for all body cancers including brain
14All of the following about PDC (pyruvate dehydrogenase complex) are true except
- ACo factor for E1 is B1, Cofactor for E2 is lipoic acid and cofactor for E3 is FAD/NAD
- BE1 is X linked
- CPDH deficiency causes lactic acidosis and a type of subacute necrotizing encephalomyelopathy (Leigh disease)
- DNone of the above
15Following all are the fates of pyruvate except
- ATransmination becomes Alanine
- BDehydrogenation becomes acetyl CoA (by PDH in the presence of Oxygen)
- CIn the absence of oxygen becomes lactate
- DCarboxylation to Oxaloacetate
- Enone of the above
16PDH kinase inactivates PDC
- ATrue
- BFalse
17The only substrate level ATP production in TCA cycle is from succinyl CoA to succinate
- ATrue
- BFalse
18TCA cycle produces NADH for OxPhos, OxPhos produces ATP
- ATrue
- BFalse
19All of the following about ETC is correct except?
- AComplex I cofactor is NADH
- BComplex II - Cofactor FADH2
- CCoQ only component of ETC not protein bound
- DComplex III - cytochrome b-c1
- EETC reduces NADH and FADH2
20All of the following statements are true except
- ARotenone is inhibitor of complex 1 in ETC
- BInhibition of Complex 1 causes a decrease in proton gradient
- COligomycin is an ATP synthase inhibitor - which increases the proton gradient
- D2,4 Dinitrophenol is an uncoupling agent - which increases proton gradient
21The primary carbon-containing molecules that are substrates for gluconeogenesis are alanine from protein degradation, lactate from anaerobic glycolysis and glycerol from fat
- ATrue
- BFalse
22All of the following are gluconeogenic enzymes except
- APyruvate carboxylase
- BPEP carboxykinase
- CFructose 1,6 bisphosphatase
- DGlucose 6 phosphatase
- ENone of the above
23All of the following are true about HMP shunt
- AProvides a source of NADPH and ribose
- BOxidative (irreversible) reaction generates NADPH
- CNon oxidative (reversible) reaction generated Ribose 5 phosphate
- Dall of the above
- E1 and 2 only
24All of the following are true about Reactive Oxygen Species
- ASOD, Catalase and Glutathione are all the enzymes that are used as a defense against oxygen toxicity
- BOH radicle attacks the C=C polyunsaturated lipid in membrane which yields malondialdehyde
- CFree radical production is part of host defense, intended to destroy microorganism and tumor cells
- DAll of the above
25Acetaminphen
- ANormal amounts of which are sulphated or glucuronated for excretion
- BExcess is oxidized by Cyp 2E1 to toxic NAPQI
- CNAPQI cannot be metabolized
- DN acetyl cysteine is the treatment for acetaminophen toxicity
26Ethanol
- ADehydrogenated to Acetaldehyde by ADH which is then dehydrogenated by ALDH to acetyl CoA
- BPyruvate is converted to lactate to generate NAD+ which can be used in the above dehydrogenase reactions as Hydrogen acceptor
- CLactic acidosis, gout, hypoglycemia and hyperlipidemia are all acute effects of ethanol metabolism
- Dall of the above are correct
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- ivenkat
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- Created on 10 Aug 2015 · updated on 19 Feb 2016
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