Flashcards
Protein Synthesis Inhibitors
Cards in this deck (9)
- 1Protein synthesis inhibitors - MupirocinNarrow spectrum against gram +ve
Bacteriostatic
substrate analogue of isoleucyl tRNA
Topical strep skin and MRSA in nares
rapidly de-esterified in kidney and liver producing non antibio metabollites - 2Protein synthesis inhibitors - Linezolids e.g. oxazolidinoneBacteriostatic against gram +ve (efflux in gram -ves restricts use)
Binds to 50s and blocks binding of isoleucyl tRNA to A site of ribosome
IV/Oral for skin and soft tissue and community acquired hospital pneumonia.
Skin, GI, Liver, thrombo, anaemia - 3Protein synthesis inhibitors - Tetracyclinesnatural and semi synthetic broad spec.
Bind to 30s, prevent association of amino acyl tRNA with ribosome
Mostly oral, some IV, some topical.
Tigecycline - IV, skin, soft tissue and intra abdominal infections.
GI, photosensitivity, CNS, deposits in bones and teeth. - 4Protein synthesis inhibitors - Aminoglycosidesnaturally occurring polycatatonic compounds.
aminohexose - aminocyclitol - aminohexose structure
Bind to 30s - strp, spectino
Bind to both - kana, tobra
causes misreading of mRNA producing abnormal proteins
IM/IV entero, pseu, plague, enterococcal endocarditis - 5Protein synthesis inhibitors - ChloramphenicolBinds to 50s inhibiting peptidyl transferase activity
natural/synthetic
Oral/IV
bone marrow depresson, gray syndroms
toxixity but treats salmonella typhi - 6Protein synthesis inhibitors - MacrolidesGram -ves especially haemophilus inf.
Bind to 23s rRNA of 50s
premature dissociation from p site
Oral/IV
Gi, jaundice - 7Protein synthesis inhibitors -Streptograminsquinopristin and dalfopristin act in synergy as synercid and bind to 50s at different sites
- 8Protein synthesis inhibitors - LincosamidesLincomycin and Clindamycin
Oral/IV bind to 50s act similar to macrolides
anaerobes and gram +ve aerobes
rashes, diarrhoea and pseudomembranous collitis c.diff - 9Protein synthesis inhibitors -Fusidic acidInterferes with elongation factor G produced from ribosome
Gram +ve
Topical oral iv staph infections
rash jaundice
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- Bsc Antibacterial Chemotherapy Flashcards on Protein Synthesis Inhibitors, created by CharlottyBow on 14/05/2013.
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