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MO24 ADME - Absorption

Mer Scott 8 preguntas

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Preguntas del test (8)

  1. 1Factors Affecting Drug Absorption:
    1. Route of [blank_start]Administration[blank_end]: the surface area, [blank_start]blood flow[blank_end] at administration site, contact time, and [blank_start]first pass[blank_end] effect
    2. [blank_start]Properties[blank_end] of the Drug: ability to [blank_start]breach[blank_end] biological barriers, chemical structure, lipid [blank_start]solubility[blank_end], molecular weight, and [blank_start]ionization[blank_end]
    3. Patient Factors: gastric [blank_start]pH[blank_end] and gastrointestinal [blank_start]motility[blank_end]
    1. AAdministration
    2. Bblood flow
    3. Cfirst pass
    4. DProperties
    5. Ebreach
    6. Fsolubility
    7. Gionisation
    8. HpH
    9. Imotility
  2. 2Lipinksi's rule of fives is a strict set of rules for if a drug can breach membranes.
    1. AVerdadero
    2. BFalso
  3. 3Lipinski defined the boundaries of good absorption potential by demonstrating that poor permeability is produced by:
    – More than [blank_start]5[blank_end] H-bond donors (sum of OHs and NHs)
    – More than [blank_start]10[blank_end] H-bond acceptors (sum of Ns and Os)
    – Molecular weight over [blank_start]500[blank_end]
    – Poor dissolution by [blank_start]log P > 5[blank_end]
    1. A5
    2. B10
    3. C500
    4. Dlog P > 5
    5. Elog P < 5
  4. 4Choose the incorrect statement about log P and drug transport.
    1. APartition coefficients influence the way drugs reach the site of action from the site of administration.
    2. BVery water-soluble drugs may be unable to cross cell membranes and reach organs rich in lipids such as brain.
    3. CVery hydrophilic drugs may be trapped in fat tissue
  5. 5Absorption from the small intestine is much greater than absorption from stomach when only considering surface area.
    1. AVerdadero
    2. BFalso
  6. 6The greater the lipophilicity of the drug, the slower it is absorbed.
    1. AVerdadero
    2. BFalso
  7. 7Acidification of urine promotes reabsorption of [blank_start]weak acids[blank_end] and excretion of [blank_start]weak bases[blank_end]. Alkalinisation of urine promotes [blank_start]reabsorption[blank_end] of weak bases and [blank_start]excretion[blank_end] of weak acids.
    1. Aweak acids
    2. Breabsorption
    3. Cexcretion
    4. Dweak bases
  8. 8In general, the greater the fraction of a drug ionised in urine, the longer the half life of the drug and vice versa.
    1. AVerdadero
    2. BFalso

Información

Descripción
(Molecules) PHCY211 Test sobre MO24 ADME - Absorption, creado por Mer Scott el 14/04/2018.
Idioma
English
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9
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