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Test

MO25 Drug action and Dose-Response

Mer Scott 10 preguntas

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Preguntas del test (10)

  1. 1What matters when considering affinity?
    1. AThe association rate constant
    2. BThe disassociation rate constant
    3. CBoth
  2. 2The [blank_start]Law of Mass Action[blank_end] for drug receptor interaction is the same principle as a chemical reaction in [blank_start]equilibrium[blank_end]. Assuming Drug and Receptor interact in a [blank_start]reversible[blank_end] manner:
    • Kon is proportional to the concentration of [blank_start]D and R[blank_end]
    • Koff is proportional to the concentration of [blank_start]DR[blank_end]
    1. Aequilibrium
    2. Breversible
    3. CLaw of Mass Action
    4. DD and R
    5. EDR
  3. 3The dissociation binding constant (Kd) is measured experimentally and is = Koff/Kon.
    1. AVerdadero
    2. BFalso
  4. 4The lower the Kd, the [blank_start]higher[blank_end] the affinity.
    1. Ahigher
    2. Blower
  5. 5Agonists are drugs that interact with and activate receptors, producing a signal. Agonists have both [blank_start]affinity[blank_end] and some [blank_start]efficacy[blank_end]
    There are different types of agonists: 'full’ agonists which activate the receptor to the [blank_start]highest response/signal level[blank_end] (full efficacy) and partial agonists which can only activate the receptor to a [blank_start]lower[blank_end] extent.
    1. Aaffinity
    2. Befficacy
    3. Chighest response/signal level
    4. Dlower
  6. 6A dose-response curve for an agonist reveals the efficacy and potency. Label them:Imagen de la pregunta 6
    1. Apotency
    2. Befficacy
  7. 7Potency is the drug [blank_start]concentration[blank_end] required to produce a specified [blank_start]response[blank_end]. It is often expressed as EC50 – concentration of drug required to produce [blank_start]half[blank_end] the maximum response.
    1. Aconcentration
    2. Bresponse
    3. Chalf
  8. 8 Antagonists are drugs that prevent an [blank_start]agonist[blank_end] from binding to a receptor and thus [blank_start]prevent[blank_end] its effects. Antagonists have [blank_start]affinity[blank_end] for the receptor but do not by themselves have any [blank_start]efficacy[blank_end]. Antagonists often are [blank_start]larger[blank_end] and make different interactions and [blank_start]more[blank_end] interactions with the receptor than an agonist.
    1. Aagonist
    2. Bprevent
    3. Caffinity
    4. Defficacy
    5. Elarger
    6. Fmore
  9. 9An antagonist moves an agonist’s dose response curve to the left.
    1. AVerdadero
    2. BFalso
  10. 10An inverse agonist is a drug that binds to a receptor and produces a pharmacological response that is [blank_start]opposite[blank_end] to that of an agonist. An inverse
    agonist [blank_start]reduces[blank_end] the activity mediated by a receptor. This works because a lot of receptors have [blank_start]intrinsic[blank_end] or constitutive activity.
    1. Aopposite
    2. Breduces
    3. Cintrinsic

Información

Descripción
(Molecules) PHCY211 Test sobre MO25 Drug action and Dose-Response, creado por Mer Scott el 14/04/2018.
Idioma
English
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