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B cell Development

Alyssa Walsh 22 preguntas

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Preguntas del test (22)

  1. 1Which of the following occurs ONLY following exposure to rabies virus?
    1. AThe synthesis of poly Ig receptors
    2. BThe appearance of rabies specific IgG in serum
    3. CThe generation of B cells with rabies specific membrane IgM and IgD
    4. DThe generation of T cells with rabies specific TCR
    5. EThe rearrangement of immunoglobulin variable region genes in B cells
  2. 2Pre-B cells
    1. AHave membrane IgM with either kappa or lambda chains
    2. BSecrete large amounts of IgM
    3. CAre found in primary lymphoid organs
    4. DCan respond to antigen to produce memory B cells
    5. EHave IgM and IgD on their membranes
  3. 3The production of hybridomas
    1. AOccurs spontaneously in mice that are immunized repeatedly
    2. BCan only be used to produce IgG
    3. CCan only be used to produce IgM antibodies
    4. DIs the major technique used to produce monoclonal antibodies
    5. EIs an experimental technique that has not yet been applied to clinical practice
  4. 4Which one of the following statements is TRUE?
    1. ASurrogate light chain is present on mature B cell
    2. BSurrogate light chain is present on naive B cell
    3. CIg-alpha/Ig-beta heterodimer is absent on mature B cells
    4. DSurrogate light chain is absent on naïve B cells
    5. EIg-alpha/Ig-beta heterodimer is absent on naive B cells
  5. 5Which one of the following statements is FALSE?
    1. AMembrane Its during developmental phase undergo somatic hypermutations
    2. BMature mouse B cells have both surface IgM and surface IgD
    3. CThose B cells that react with self-antigens during developmental phase can be deleted
    4. DMemory B cells are long lived cells and play a role in secondary antibody responses
    5. EAll immunoglobulins on a mature B cell are specific to only one particular epitope
  6. 6 Which one of the following statements is FALSE?
    1. AAt pre-B cell stage, the heavy chain is present along with a surrogate light chain
    2. BIn an immature B cell both IgM and IgD are expressed on the B cell surface
    3. CA B-cell has gone through V(D)J rearrangement when it is a pre-B cell
    4. DLong lived memory B-cells express IgG, IGA, or IgE on the surface
  7. 7Which one of the following statements is TRUE?
    1. AWhen an immature B cell interacts with an antigen it results in clonal expansion
    2. BDifferentiation into a plasma cell occurs before a B-cell is activated
    3. CDuring the early stages of a primary immune response a plasma cell will secrete IgM
    4. DMemory B cells have the ability to secrete immunoglobulins
  8. 8In all B cell stages, [blank_start]CD19[blank_end] is present but not on T cells. From the immature to memory B cell stages, [blank_start]CD20[blank_end] is expressed.
    1. ACD19
    2. BCD20
  9. 9Somatic hypermutation and Class switch recombination both require:
    1. ATdT- terminal deoxynucleotidyl transferase
    2. BAID- activation induced cytidine deaminase
    3. CRAG-1/RAG-2: Recombination-activating genes 1 and 2 proteins
  10. 10T cells are needed to signal B cells to undergo what?
    1. ACSR
    2. BSHM
    3. CCSR and SHM
    4. DMemory cell formation
    5. EAll of the above
    6. FNone of the above

Información

Descripción
Immunology Test sobre B cell Development , creado por Alyssa Walsh el 07/10/2021.
Idioma
English
Visitas
5
Etiquetas
immunology
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