Quiz
B cell Development
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Questions in this quiz (22)
1Which of the following occurs ONLY following exposure to rabies virus?
- AThe synthesis of poly Ig receptors
- BThe appearance of rabies specific IgG in serum
- CThe generation of B cells with rabies specific membrane IgM and IgD
- DThe generation of T cells with rabies specific TCR
- EThe rearrangement of immunoglobulin variable region genes in B cells
2Pre-B cells
- AHave membrane IgM with either kappa or lambda chains
- BSecrete large amounts of IgM
- CAre found in primary lymphoid organs
- DCan respond to antigen to produce memory B cells
- EHave IgM and IgD on their membranes
3The production of hybridomas
- AOccurs spontaneously in mice that are immunized repeatedly
- BCan only be used to produce IgG
- CCan only be used to produce IgM antibodies
- DIs the major technique used to produce monoclonal antibodies
- EIs an experimental technique that has not yet been applied to clinical practice
4Which one of the following statements is TRUE?
- ASurrogate light chain is present on mature B cell
- BSurrogate light chain is present on naive B cell
- CIg-alpha/Ig-beta heterodimer is absent on mature B cells
- DSurrogate light chain is absent on naïve B cells
- EIg-alpha/Ig-beta heterodimer is absent on naive B cells
5Which one of the following statements is FALSE?
- AMembrane Its during developmental phase undergo somatic hypermutations
- BMature mouse B cells have both surface IgM and surface IgD
- CThose B cells that react with self-antigens during developmental phase can be deleted
- DMemory B cells are long lived cells and play a role in secondary antibody responses
- EAll immunoglobulins on a mature B cell are specific to only one particular epitope
6 Which one of the following statements is FALSE?
- AAt pre-B cell stage, the heavy chain is present along with a surrogate light chain
- BIn an immature B cell both IgM and IgD are expressed on the B cell surface
- CA B-cell has gone through V(D)J rearrangement when it is a pre-B cell
- DLong lived memory B-cells express IgG, IGA, or IgE on the surface
7Which one of the following statements is TRUE?
- AWhen an immature B cell interacts with an antigen it results in clonal expansion
- BDifferentiation into a plasma cell occurs before a B-cell is activated
- CDuring the early stages of a primary immune response a plasma cell will secrete IgM
- DMemory B cells have the ability to secrete immunoglobulins
8In all B cell stages, [blank_start]CD19[blank_end] is present but not on T cells. From the immature to memory B cell stages, [blank_start]CD20[blank_end] is expressed.
- ACD19
- BCD20
9Somatic hypermutation and Class switch recombination both require:
- ATdT- terminal deoxynucleotidyl transferase
- BAID- activation induced cytidine deaminase
- CRAG-1/RAG-2: Recombination-activating genes 1 and 2 proteins
10T cells are needed to signal B cells to undergo what?
- ACSR
- BSHM
- CCSR and SHM
- DMemory cell formation
- EAll of the above
- FNone of the above
11The surrogate light chain of Pre-B cell receptors contains 2 domains which are called [blank_start]VpreB[blank_end] and [blank_start]λ5[blank_end].
- AVpreB
- Bλ5
12Antibodies used for research, diagnosis, or therapy are polyclonal and monoclonal antibodies.
- ATrue
- BFalse
13A home pregnancy test is an indirect ELISA for human chorionic gonadotropin (hCG)
- ATrue
- BFalse
14In the absence of T helper cell help, B cells will make mostly IgM Ab response
- ATrue
- BFalse
15In the absence of T helper cell help, B cells will make strong secondary IgG response
- ATrue
- BFalse
16In the absence of ThC help, germinal centers will not form
- ATrue
- BFalse
17Follicular DCs have Ags bound to their surface which play a role in affinity maturation of Ab molecules
- ATrue
- BFalse
18Cytokines released by ThCs are required for class switch recombination
- ATrue
- BFalse
19The first recombination event during B cell development is VJ recombination at the Ig heavy chain locus
- ATrue
- BFalse
20In the absence of RAG1, B cells will be missing but T cells will be present at normal levels
- ATrue
- BFalse
21Flow cytometry is a technique that uses Abs labeled with [blank_start]fluorochromes[blank_end] and the cells that are "labeled" by the Ab are detected using a flow cytometer.
- Afluorochromes
22What are some applications for flow cytometry?
- Aimmunophenotyping
- Bmeasuring T cell responses
- Cmicrobial identification
- DCancer diagnosis
- Enone of the above
- Fall of the above
Information
- Description
- Immunology Quiz on B cell Development , created by Alyssa Walsh on 07/10/2021.
- Author
- Alyssa Walsh
- Language
- English
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