Methods

Methods

1. Conceptual Approaches

   • Logical reasoning
     • inductive
     • deductive
     • Scientific Method
       • Observation
         • Research
           • Hypothesis
             • Experiment
               • Results
                 • Conclusion
               • use methods/techniques

2. Techniques

   • neuroanatomy
     • histology
       • light microscopy
       • electron microscopy
       • confocal and 2-photon microscopy
     • general stains
       • Nissl
       • DAPI
       • Golgi
     • specific staining
       • IHC
     • brain imaging
       • CT
       • MRI
       • PET
   • lesion studies
     • unintentional defect/damage
       • trauma/infection
       • mutation
     • directed/intentional
       • lesions
         • permanent
         • temporary
           • Chemical
       • mutations
         • targeted mutations
   • measuring brain activity
     • neurophysiology
     • imaging
       • EEG
       • PET
       • fMRI
     • animals
       • in vivo or in vitro
       • intracellular or extracellular
       • IEG
       • Ca++ imaging
   • brain stimulation
     • electrical stimuli
       • DBS
     • optogenetics

3. non-experimental

   • describe brain structure or activity
   • correlational studies
     • correlation is not causation!

4. experimental

   • true experiment
     • independent variable
     • dependent variable
   • quasi-experiment