Enzymology

Enzymology

1. Tissue specific enzymes can be diagnostically useful

2. Induced

   • ALP GGT
   • rarely increased due to cell injury
   • increased production

3. Leakage

   • ALT AST SDH GLDH CK
   • Injury to cell membranes or organelles
     • severe as cell death
     • mild as increased cell permeability

4. Alkaline phosphatase (ALP)

   • sources
     • LIVER
       • long lived
         • 3 days
     • GI, Placenta, Kidney
       • short-lived
         • minutes

5. GGT

   • Excreted in urine
   • released into serum by hepatocytes

6. ALT

   • difficult to determine magnitude of damage