Immunity to infections

Immunity to infections

1. Histatins

   • Exaggerated reaction
   • Type 1 - IV
   • Dental allergens

2. Recap

   • Innate
     • Phagocytosis
   • Adaptive
     • B - Lymphocytes
     • T Lymphocytes

3. Terminology

   • Lysozyme
     • Help antimicrobial peptides be more effective
     • Bond between peptidoglycan layer and cell wall
   • IgA
     • Most abundant in saliva
   • IgG, IgM
     • GCF

4. Host defence peptides

   • Cationic
   • Histatins
   • Saliva + GCF
   • Defensins
     • Alpha and beta
   • LL-37
     • Only cathelicidin in humans

5. Defensins

   • 6 - cysteine, 3 - disulphide bonds
   • Need to be proteolytically cleaved to be active
   • Alpha & beta

6. LL-37

   • Produced by leucocytes and epithelial cells
   • Alpha - helical structure