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L12 Structure Activity Relationships

Mer Scott 14 preguntas

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Preguntas del test (14)

  1. 1Choose the correct statement about structure activity relationships.
    1. AThey are the relationship between chemical structure and pharmacological activity for a series of molecules.
    2. BThey are the relationships between chemical structure and pharmacological activity for a molecule.
  2. 2The defined pharmacological activity can [blank_start]vary[blank_end] greatly. It could be a binding interaction with a [blank_start]specific[blank_end] receptor, a functional readout of compound [blank_start]activity[blank_end], toxicity, drug adsorption, and much more.
    1. Avary
    2. Bspecific
    3. Cactivity
  3. 3Generally SAR analysis is [blank_start]qualitative[blank_end]. however, the field of research to mathematically quantify SARs is known as QSAR – [blank_start]quantitative[blank_end] structure activity relationships
    1. Aqualitative
    2. Bquantitative
  4. 4Choose the incorrect statement about QSARs.
    1. AIt is a statistical algorithm that quantitatively defines the relationship between the chemical structure of a drug and its effect on an organism
    2. BQSARs save money because they can be done without cost of synthesis and biological assays
    3. CQSARs do not promote green chemistry because they are done on computers
  5. 5By rationalising the mechanisms of action within a series of drugs we can a) design new drugs or b) make better drug choices from a class of drugs to:
    (select all correct)
    1. AIncrease drug potency
    2. BDecrease stability of drug
    3. CDecrease toxicity of drug
    4. DIncrease or decrease duration of action
    5. EIncrease selectivity
  6. 6The ‘pattern’ of what a pharmacophore is can be found from SAR studies
    1. AVerdadero
    2. BFalso
  7. 7What can we use to quantify the relationships between functional groups in the 3D pharmacophore(QSAR)?
    1. AVectors
    2. BAngles
    3. CDescriptive terms
  8. 8For a flexible molecule with many conformations, it is easier to identify the pharmacophore.
    1. AVerdadero
    2. BFalso
  9. 9Molecular structure and biological activity are correlated by observing the [blank_start]experimental[blank_end] results of systematic structural [blank_start]modification[blank_end] on defined biological endpoints. The relevance of a functional group to binding can be determined by synthesising analogues where the functional group is slightly [blank_start]modified or removed[blank_end], then this molecule tested to [blank_start]compare[blank_end] the difference.
    1. Aexperimental
    2. Bmodification
    3. Cmodified or removed
    4. Dcompare
  10. 10Steric bulk influences binding. You can [blank_start]change[blank_end] the steric bulk gradually, test each iteration, and develop an understanding of the [blank_start]optimal[blank_end] structure for the desired biological activity. For ligand-receptor interactions, sometimes [blank_start]bulky[blank_end] is better, sometimes it's worse; it’s about finding the optimal ligand-receptor fit.
    1. Achange
    2. Boptimal
    3. Cbulky

Información

Descripción
(Molecules) PHCY211 Test sobre L12 Structure Activity Relationships, creado por Mer Scott el 10/04/2018.
Idioma
English
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