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Test

MO30 Phase 1 Drug Metabolism

Mer Scott 12 preguntas

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Este test tiene tipos de pregunta que se abren en el reproductor de siempre.

Preguntas del test (12)

  1. 1Identify the major and minor products of aliphatic oxidation of pentobarbital.Imagen de la pregunta 1
    1. Amajor product
    2. Bminor product
  2. 2Label the compounds by their active groups, and also label the chemical vs enzymatic pathways.Imagen de la pregunta 2
    1. Aepoxide
    2. Bphenol
    3. Cdiol (catechol)
    4. DEnzymatic
    5. EChemical
  3. 3Reactivity in Aromatic Oxidation mechanism is analogous to electrophilic aromatic substitution reactions
    in organic chemistry:
    • electron-donating substituents [blank_start]enhance[blank_end] metabolic oxidation
    • electron-withdrawing substituents [blank_start]reduce or prevent[blank_end] oxidation
    • oxidation occurs at the [blank_start]least[blank_end] hindered position
    • if two rings are present [blank_start]only one is[blank_end] usually oxidised
    1. Aenhance
    2. Breduce or prevent
    3. Cleast
    4. Dmost
    5. Eonly one is
    6. Fboth are
  4. 4Dealkylation is loss of alkyl groups attached to [blank_start]O, N or S[blank_end] atoms.
    The mechanism is [blank_start]hydroxylation[blank_end] of the nearest aliphatic/alpha [blank_start]carbon[blank_end], followed by hydrolytic cleavage to give the corresponding [blank_start]phenols, amines and thiols[blank_end]. Forms an [blank_start]ether[blank_end] as well.
    There must be an alpha [blank_start]hydrogen[blank_end] present, i.e. Aromatic ring—X—CR3 would be resistant (X = O, N or S).
    1. AO, N or S
    2. Bhydroxylation
    3. Ccarbon
    4. Dphenols, amines and thiols
    5. Eether
    6. Fhydrogen
  5. 5In O-deakylation, the hemiacetal intermediate is unstable and dissociates to form an aldehyde or ketone.
    1. AVerdadero
    2. BFalso
  6. 6Choose the incorrect statement.
    1. AIn O-deakylation, the hemiacetal intermediate is unstable and dissociates to form an aldehyde or ketone.
    2. BN-dealkylation proceeds via a carbinolamine which is unstable and dissociates to form an amine and an aldehyde.
    3. CS-dealkylation is rather uncommon because sulfur containing drugs are uncommon and the S atom is more susceptible to oxidation than the adjacent C-H bond.
  7. 7Primary aliphatic amines with no alpha-H like are oxidised to [blank_start]hydroxylamines[blank_end]. [blank_start]Secondary[blank_end] amines are also oxidised to hydroxylamines. Tertiary amines are oxidised to [blank_start]N-oxides[blank_end]. These N-oxidations are catalysed by either [blank_start]CYP450s[blank_end] or flavin-containing monooxygenases ([blank_start]FMOs[blank_end]).
    1. Ahydroxylamines
    2. BN-oxides
    3. CSecondary
    4. DCYP450s
    5. EFMOs
  8. 8Label the amines and product amine groups.Imagen de la pregunta 8
    1. APrimary amine
    2. BSecondary amine
    3. CTertiary amine
    4. DPrimary amine
    5. ESecondary amine
    6. FTertiary amine
    7. GPrimary amine
    8. HSecondary amine
    9. ITertiary amine
    10. JHydroxylamine
    11. KN-oxide
    12. LHydroxylamine
    13. MN-oxide
    14. NHydroxylamine
    15. ON-oxide
  9. 9S-oxidation is catalysed by the enzyme flavin-containing monoxygenase.
    1. AVerdadero
    2. BFalso
  10. 10Deamination occurs when the [blank_start]C-N[blank_end] bond linking the amino group to the bulk of the molecule is cleaved. Oxidative deamination converts primary aliphatic amines to [blank_start]aldehydes/ketones[blank_end]. Most deamination is via [blank_start]monoamine oxidase (MAO)[blank_end] which degrades endogenous catecholamines, but some still occur via [blank_start]CYP450s[blank_end].
    1. AC-N
    2. Baldehydes/ketones
    3. Cmonoamine oxidase (MAO)
    4. DCYP450s

Información

Descripción
(Molecules) PHCY211 Test sobre MO30 Phase 1 Drug Metabolism, creado por Mer Scott el 15/04/2018.
Idioma
English
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